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The Voices of Stakeholders Involved in Precision Medicine

The Co-Design and Evaluation of Qualitative Indicators of Intervention Acceptability, Fidelity and Context in PRecISion Medicine for Children With Cancer in Australia

Bibliographic Data

ID4710946
AuthorsJames Smith (0000-0002-0448-8774, Macquarie University, corresponding author), Jeffrey Braithwaite (0000-0003-0296-4957, Macquarie University), Tracey A O’brien (UNSW Sydney), Tracey O’brien (0000-0002-5759-6162, UNSW Sydney), Stephanie Smith (0000-0002-6892-4379, Curtin University), Vanessa J Tyrrell (Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia), Vanessa Tyrrell (0000-0002-5162-517X, UNSW Sydney), Emily V A Mould (Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia), Emily Mould (UNSW Sydney), Janet C Long (0000-0002-0553-682X, Macquarie University), F Rapport (0000-0002-4428-2826, Macquarie University)
Year2022
Volume32
Issue12
Pages1865-1880
Publication date2022-10-01
Open AccessYes
TypeARTICLE
VenueQualitative Health Research (JOURNAL)
Journal identifiersISSN: 1049-7323 • E-ISSN: 1552-7557
PublisherSAGE Publications Inc (PUBLISHER)
DOI10.1177/10497323221120501
PMID36066496
OpenAlexW4294788374
LanguageEN
Citations received2
References cited62

We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context

Comprehension · Data collection · Fidelity · Medical education · Multidisciplinary approach · Precision medicine · Qualitative property · Qualitative research · Receipt · Applied Psychology · Computer Science · Health Policy Implementation Science · Health Systems, Economic Evaluations, Quality of Life · Medicine · Mental Health and Patient Involvement · Nursing · Psychology

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Citations per year0.67
Citation span2023 - 2026 (4)
Highly citedNo

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