The relationship between cognitive decline and a genetic predictor of educational attainment
Bibliographic Data
| ID | 4790455 |
|---|---|
| Authors | Xuejie Ding (0000-0002-0280-8463, University of Oxford, corresponding author), Nicola Barban (0000-0002-4362-4652, Institute for Social and Economic Research), Felix C Tropf (0000-0003-2445-515X, Centre de Recherche en Économie et Statistique), Melinda C Mills (0000-0003-1704-0001, Leverhulme Trust) |
| Year | 2019 |
| Volume | 239 |
| Pages | 112549 |
| Publication date | 2019-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Social Science & Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0277-9536 • E-ISSN: 1873-5347 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.socscimed.2019.112549 |
| PMID | 31546143 |
| OpenAlex | W2972529548 |
| Language | EN |
| Citations received | 9 |
| References cited | 74 |
Genetic and environmental factors both make substantial contributions to the heterogeneity in individuals' levels of cognitive ability. Many studies have examined the relationship between educational attainment and cognitive performance and its rate of change. Yet there remains a gap in knowledge regarding whether the effect of genetic predictors on individual differences in cognition becomes more or less prominent over the life course. In this analysis of over 5000 older adults from the Health and Retirement Study (HRS) in the U.S., we measured the change in performance on global cognition, episodic memory, attention & concentration, and mental status over 14 years. Growth curve models are used to evaluate the association between a polygenic risk score for education (education PGS) and cognitive change. Using the most recent education PGS, we find that individuals with higher scores perform better across all measures of cognition in later life. Education PGS is associated with a faster decline in episodic memory in old age. The relationships are robust even after controlling for phenotypic educational attainment, and are unlikely to be driven by mortality bias. Future research should consider genetic effects when examining non-genetic factors in cognitive decline. Our findings represent a need to understand the mechanisms between genetic endowment of educational attainment and cognitive decline from a biological angle
Cognition · Cognitive decline · Dementia · Developmental psychology · Disease · Economics · Educational attainment · Effects of sleep deprivation on cognitive performance · Endowment · Episodic memory · Psychiatry · Sociology · Working memory · Birth, Development, and Health · Cognitive Abilities and Testing · Demography · Health, Environment, Cognitive Aging · Medicine · Psychology · Gerontology
Cognitive Aging Among First-Generation College Graduates and Those With Different Educational Backgrounds
Examining Differences in the Predictive Capacity of Educational Polygenic Scores on Physical Limitations Among Older Adults With European or African Ancestry
Volunteering, polygenic risk for Alzheimer's disease, and cognitive functioning among older adults
Heterogenous trajectories in physical, mental and cognitive health among older Americans
Using sibling models to unpack the relationship between education and cognitive functioning in later life
Nirvana
Causal Effects of Schooling on Memory at Older Ages in Six Low- and Middle-Income Countries
Sibling Deaths, Racial/Ethnic Disadvantage, and Dementia in Later Life
Declined prevalence, improved awareness and control of hypertension are associated with spousal educational attainment
Cognitive reserve☆
Principal components analysis corrects for stratification in genome-wide association studies
Polygenic Influence on Educational Attainment
Predictors of cognitive change in older persons
Consequences of Age-Related Cognitive Declines
Genetic and environmental influences on human psychological differences
Trajectories of Cognitive Function in Late Life in the United States
Intelligence
The Genetics of Success
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
The nature of nurture
Genome-wide association study identifies 74 loci associated with educational attainment
Older Adults' Reasons for Using Technology while Aging in Place
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Twelve Frequently Asked Questions About Growth Curve Modeling
Gene × Environment Interaction Studies Have Not Properly Controlled for Potential Confounders
“Mini-mental state”
Education and the Risk of Alzheimer's Disease
Measures of Cognitive Functioning in the Ahead Study
Assessment of Cognition Using Surveys and Neuropsychological Assessment
Shared and unique genetic and environmental influences on aging-related changes in multiple cognitive abilities
The cognitive reserve hypothesis
Childhood socioeconomic status and genetic risk for poorer cognition in later life
Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population
Education, Smoking, and Cohort Change
Socio-Genomic Research Using Genome-Wide Molecular Data
| Unique citing works | 9 |
|---|---|
| Citations per year | 1,5 |
| Citation span | 2020 - 2026 (7) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 9 |