Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil
Bibliographic Data
| ID | 5166109 |
|---|---|
| Authors | Flavio De Carvalho (0000-0002-0020-0331, Fundação Oswaldo Cruz), Luciana Gomes Pedro Brandão (0000-0002-5271-422X, Fundação Oswaldo Cruz, corresponding author), Marisa Carvalho Varela (0000-0002-8161-1158, Fundação Oswaldo Cruz), Mari Tuyama (0000-0002-0082-5155, Fundação Oswaldo Cruz), Danusa Ferreira Correa (0000-0002-6121-6919, Fundação Oswaldo Cruz), Ananza Taina Da Silva Santos (0000-0002-3826-5528, Fundação Oswaldo Cruz), Alberto Dos Santos De Lemos (0000-0003-0138-6577, Fundação Oswaldo Cruz, Brazil; Universidade Federal do Rio de Janeiro, Brazil), Marcellus Dias Da Costa (0000-0003-2493-5583, Fundação Oswaldo Cruz), José Cerbino-Neto (0000-0001-9254-917X, Fundação Oswaldo Cruz), Pedro Emmanuel Alvarenga Americano Do Brasil (0000-0002-6700-2268, Fundação Oswaldo Cruz) |
| Year | 2023 |
| Volume | 39 |
| Issue | 2 |
| Pages | e00075522-e00075522 |
| Publication date | 2023-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311xen075522 |
| PMID | 36946796 |
| OpenAlex | W4353018201 |
| SCIELO_PID | S0102-311X2023000205004 |
| Language | EN |
| References cited | 20 |
The objectives were to estimate hepatitis A virus seroprevalence in subjects attending to a travel medicine and immunization clinic in Rio de Janeiro, Brazil, and to develop a prediction model for hepatitis A virus seroprevalence. This retrospective research included individuals sequentially from April 2011 to June 2019 at a travel medicine and special population immunization clinic with an anti-hepatitis A virus IgG chemiluminescence result. Participants' data were verified via electronic medical records. Data were split into development and validation set taking 2018 as the date break. A cross-validated elastic generalized linear model with binomial distribution was performed. In total, 2,944 subjects were analyzed. Hepatitis A virus overall seroprevalence was 67.8%. Health professionals, travelers, and those who had contact with immunocompromised subjects had lower seroprevalence (40%-55%), whereas subjects with chronic conditions (heart, lung, and liver) ranged from 89% to 94%. The retained predictors in the final model were sex, age, year of birth, travelers, HIV/AIDS, spleen dysfunction, transplant candidates, household communicators, cancer-related immunosuppression, health care professionals. Area under the curve was 0.836 and maximum error was 0.051. Users can make predictions with the following calculator: https://pedrobrasil.shinyapps.io/INDWELL/. The groups with lower seroprevalence should be evaluated more carefully regarding need for hepatitis A virus vaccination even when they seek immunization clinics for other purposes
Antibody · Environmental health · Family medicine · Hepatitis · Hepatitis A · Population · Serology · Seroprevalence · Demography · Hepatitis Viruses Studies and Epidemiology · Immunology · Medicine · Travel-related health issues · Viral gastroenteritis research and epidemiology
| Citation velocity | historical |
|---|---|
| Highly cited | No |