Birth conditions nutritional status in childhood associated with cardiometabolic risk factors at 30 years of age
A Cohort Study
Bibliographic Data
| ID | 5166149 |
|---|---|
| Authors | Vânia Pereira Oliveira (0000-0001-7240-0992, Universidade Federal de Pelotas), Mariane Da Silva Dias (0000-0003-4995-4748, Universidade Federal de Pelotas, Brazil; Universidade Federal do Rio Grande, Brazil), Natália Peixoto Lima (0000-0002-7181-3717, Universidade Federal de Pelotas), Bernardo L Horta (0000-0001-9843-412X, Universidade Federal de Pelotas) |
| Year | 2023 |
| Volume | 39 |
| Issue | 6 |
| Pages | e00215522-e00215522 |
| Publication date | 2023-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311xen215522 |
| PMID | 37377296 |
| OpenAlex | W4382136276 |
| SCIELO_PID | S0102-311X2023000605002 |
| Language | EN |
| References cited | 24 |
This study aimed to assess the association of birth conditions, nutritional status, and childhood growth with cardiometabolic risk factors at 30 years of age. We also evaluated whether body mass index (BMI) at 30 years mediated the association of weight gain in childhood with cardiometabolic risk factors. This is a prospective cohort study that included all live births in 1982 in hospitals in the city of Pelotas, Rio Grande do Sul State, Brazil, whose families lived in the urban area. Mothers were interviewed at birth, and participants were followed at different ages. For our analyses, we used data on weight and height collected at birth, 2 and 4 years and cardiovascular risk factors at 30 years. Multiple linear regressions were performed to obtain adjusted coefficients and G-formula for mediation analysis. Relative weight gain in childhood, despite the age, was positively related to mean arterial pressure, whereas relative weight gain in late childhood was positively associated with carotid intima-media thickness, pulse wave velocity, triglycerides, non-HDL cholesterol, plasma glucose, and C-reactive protein. BMI in adulthood captured the total effect of relative weight gain in the period between 2 and 4 years on carotid intima-media thickness, triglycerides, non-HDL cholesterol, and C-reactive protein. Our findings reinforce the evidence that rapid relative weight gain after 2 years of age may have long-term consequences on the risk of metabolic and cardiovascular disorders
Biology · Birth weight · Body mass index · Body weight · Carotid arteries · Cohort · Cohort study · Confidence interval · Intima-media thickness · Mediation · Pregnancy · Prospective cohort study · Relative risk · Weight gain · Birth, Development, and Health · Child Nutrition and Water Access · Demography · Internal Medicine · Medicine · Obesity, Physical Activity, Diet · Pediatrics
The double burden of malnutrition
Cohort Profile
Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income
Maternal and child undernutrition
Birth weight, postnatal weight gain, and adult body composition in five low and middle income countries
Worldwide implementation of the WHO Child Growth Standards
Adolescent blood pressure, body mass index and skin folds
| Citation velocity | historical |
|---|---|
| Highly cited | No |