Intrauterine growth restriction, prematurity, and low birth weight

Risk phenotypes of neonatal death, Rio de Janeiro State, Brazil

Bibliographic Data

ID5166527
AuthorsPauline Lorena Kale (0000-0001-5439-9158, Universidade Federal do Rio de Janeiro, corresponding author), Sérgio C Fonseca (0000-0001-5493-494X, Universidade Federal Fluminense)
Year2023
Volume39
Issue6
Publication date2023-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311xen231022
OpenAlexW4382134022
SCIELO_PIDS0102-311X2023000605003
LanguageEN
References cited34

Intrauterine growth restriction and prematurity determine low birth weight. The combination of the three conditions results in different neonatal phenotypes that interfere with child survival. Neonatal prevalence, survival and mortality were estimated according to neonatal phenotypes in the cohort of live births in 2021 in the state of Rio de Janeiro, Brazil. In this study, live births of multiple pregnancies, with congenital anomalies and inconsistencies in the information of weight and gestational age were excluded. The Intergrowth curve was used to classify weight adequacy. Mortality (< 24 hours, 1-6 and 7-27 days) and survival (Kaplan-Meier) were estimated. In total, 6.8%, 5.5%, and 9.5% of the 174,399 live births were low birth weight, small for gestational age (SGA), and premature, respectively. Considering low birth weight live births, 39.7% were SGA and 70% were premature. The neonatal phenotypes were heterogeneous according to maternal, delivery, pregnancy, and newborn characteristics. The mortality rate per 1,000 live births was high for low birth weight premature newborns, both SGA (78.1) and AGA (adequate for gestational age: 61.1), at all specific ages. Reductions in the survival rate were observed when comparing non-low birth weight and AGA term live births. The estimated prevalence values were lower than those of other studies, partly due to the exclusion criteria adopted. The neonatal phenotypes identified children who were more vulnerable and at higher risk of death. Prematurity contributed more to mortality than SGA, and its prevention is necessary to reduce neonatal mortality in the state of Rio de Janeiro

Biology · Birth weight · Environmental health · Gestation · Gestational age · Infant mortality · Intrauterine growth restriction · Live birth · Low birth weight · Neonatal mortality · Obstetrics · Population · Pregnancy · Small for gestational age · Birth, Development, and Health · Global Maternal and Child Health · Medicine · Pregnancy and preeclampsia studies · Pediatrics

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