New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence

The Pedia scale

Bibliographic Data

ID5166686
AuthorsCelline Cardoso Almeida-Brasil (0000-0002-6324-4702, Universidade Federal de Minas Gerais), Emerson Do Nascimento (0000-0002-3244-2271, Universidade Federal de Minas Gerais), Micheline Rosa Silveira (0000-0001-7002-4428, Universidade Federal de Minas Gerais), Palmira De Fátima Bonolo (0000-0003-2744-7139, Universidade Federal de Minas Gerais), Maria Das Graças B Ceccato (0000-0002-4340-0659, Universidade Federal de Minas Gerais)
Year2019
Volume35
Issue5
Pagese00184218-e00184218
Publication date2019-01-01
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311x00184218
PMID31166419
OpenAlexW2947918122
SciELOS0102-311X2019000604002
LanguageEN
Citations received3
References cited30

This study sought to develop and evaluate a new patient-reported outcome measure to assess perceived barriers to antiretroviral therapy (ART) adherence. The Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) scale was developed based on individual interviews with patients. After pilot testing and assessing the evidence based on content analysis, the scale's revisions resulted in a 40-item version. The PEDIA was applied to 415 HIV-infected adults receiving ART for a maximum of 180 days, recruited from three healthcare facilities of reference in the city of Belo Horizonte, Minas Gerais State, Brazil. The analyses included exploratory factor analysis, internal consistency, item response theory, temporal stability, and predictive test-criterion relationship. The scale's final version contains 18 items distributed in three dimensions, as follows: cognitive and routine problems (4 items); medication and health concerns (6 items); and patient's fears and feelings (8 items). The results of McDonald's omega and temporal stability demonstrate that the PEDIA is internally consistent and yields stable scores over time. The assessment of the information's functions suggested that the three dimensions were informative for assessing a broad range of latent traits. Evidence concerning the test-criterion relationship confirmed that the PEDIA was able to predict non-adherence three months later. Our findings suggest that the PEDIA is a psychometrically adequate tool for evaluating perceived barriers in adult patients initiating ART. It could be used in both research and clinical practice for the early detection of patients at risk of non-adherence and for the identification of potentially modifiable barriers

Antiretroviral therapy · Exploratory factor analysis · Family medicine · Feeling · Human immunodeficiency virus (HIV) · Psychometrics · Scale (ratio) · Test (biology) · Viral load · Adolescent Sexual and Reproductive Health · Clinical Psychology · HIV/AIDS Research and Interventions · LGBTQ Health, Identity, and Policy · Medicine · Psychology · Social Psychology

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