Cohort profile
Follow-up of a household cohort throughout five epidemic waves of Sars-CoV-2 in Rio de Janeiro, Brazil
Dados Bibliográficos
| ID | 5168923 |
|---|---|
| Autores | Michele Fernanda Borges Da Silva (0000-0001-5710-4124, Fundação Oswaldo Cruz), Lusiele Guaraldo (0000-0003-0047-6538, Fundação Oswaldo Cruz), Heloisa Ferreira Pinto Santos (0000-0002-6353-9172, Fundação Oswaldo Cruz), Leonardo Soares Bastos (0000-0002-1406-0122, Fundação Oswaldo Cruz), Anielle De Pina-Costa (0000-0002-5527-2295, Fundação Oswaldo Cruz), Stephanie Lema Suarez Penetra (0000-0002-0943-8776, Fundação Oswaldo Cruz), Isabella Campos Vargas De Moraes (0000-0002-7797-6971, Fundação Oswaldo Cruz), Guilherme Amaral Calvet (0000-0002-3545-5238, Fundação Oswaldo Cruz), Tamara L Fuller (0000-0001-9954-4267, University of California, USA), Patrick Costa Ribeiro Silva (0000-0002-2884-3662, Fundação Oswaldo Cruz), Marilda Agudo Mendonça Teixeira De Siqueira (0000-0003-4685-9817, Fundação Oswaldo Cruz), Patricia Brasil (0000-0001-9555-7976, Fundação Oswaldo Cruz) |
| Ano | 2024 |
| Volume | 40 |
| Fascículo | 7 |
| Páginas | e00152023-e00152023 |
| Data de publicação | 2024-01-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Cadernos de Saude Publica (JOURNAL) |
| Identificadores do periódico | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Editora | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311xen152023 |
| PMID | 39194089 |
| OpenAlex | W4401816923 |
| SCIELO_PID | S0102-311X2024000701408 |
| Idioma | EN |
| Referências citadas | 18 |
Since May 2020, we have been conducting a comprehensive study to understand the natural history of SARS-CoV-2 infection in Rio de Janeiro, Brazil. Our focus has been on following families, systematically collecting respiratory tract swabs and blood samples, monitoring symptoms, and gathering data on vaccine status. This paper aims to describe the household cohort across five epidemic waves of SARS-CoV-2, providing an overview of the collected data and a description of the epidemiological, clinical, and immunological characteristics and incidence of SARS-CoV-2 infection. Our cohort includes 691 participants from 189 households. During the five epidemic waves, we detected 606 infections. The incidence density of SARS-CoV-2 infection ranged from 4 (Delta) to 56 (B.1.1.33) per 1,000 person-week, with a peak in wave B.1.1.33 in all age groups. The seroprevalence of SARS-CoV-2 antibodies (IgG anti spike protein) varied from 37%, in the pre-VoC period, to 99%, in the Omicron period, progressively increasing after each wave in a similar manner regardless of age. As we have monitored the cohort continuously since the beginning of the pandemic, we were able to collect data across different scenarios according to the predominant lineage in circulation. Via active monitoring of families, we were able to carry out an epidemiological surveillance on SARS-CoV-2, including its variants, persistence of symptoms, and changes in immunity over time in the population, contributing to knowledge of the natural history of SARS-CoV-2 infection
Antibody · Cohort · Cohort study · Coronavirus disease 2019 (COVID-19) · Disease · Environmental health · Incidence (geometry) · Infectious disease (medical specialty) · Natural history · Pandemic · Population · Serology · Seroprevalence · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) · COVID-19 Clinical Research Studies · Demography · Epidemiology · Immunology · Internal Medicine · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Virology
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| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |