Fructose-induced FGF21 secretion does not activate brown adipose tissue in Japanese young men
Randomized Cross-Over and Randomized Controlled Trials
Bibliographic Data
| ID | 5180844 |
|---|---|
| Authors | Haruki Kataoka, Shinsuke Nirengi (0000-0003-1881-067X, The Ohio State University Wexner Medical Center), Yuka Matsui (Kyoto Prefectural University), Hirokazu Taniguchi (0000-0001-7999-8456, Kyoto Prefectural University, corresponding author) |
| Year | 2024 |
| Volume | 43 |
| Issue | 1 |
| Pages | 5-5 |
| Publication date | 2024-01-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of PHYSIOLOGICAL ANTHROPOLOGY (JOURNAL) |
| Journal identifiers | ISSN: 1880-6791 • E-ISSN: 1880-6805 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s40101-023-00353-0 |
| PMID | 38178259 |
| OpenAlex | W4390583079 |
| Language | EN |
| Citations received | 1 |
| References cited | 50 |
Background Human brown adipose tissue (BAT) activity is associated with lower body fatness and favorable glucose metabolism. Previous studies reported that oral fructose loading induces postprandial fibroblast growth factor 21 (FGF21) secretion. FGF21 is a known inducer of adipose tissue thermogenesis; however, the effects of diet-induced FGF21 secretion on BAT thermogenesis remain to be elucidated. Methods The effects of both single load and daily consumption of fructose on BAT activity were examined using a randomized cross-over trial and a 2-week randomized controlled trial (RCT), respectively. In the cross-over trial, 15 young men consumed a single dose of fructose solution or water and then consumed the other on a subsequent day. The RCT enrolled 22 young men, and the participants were allocated to a group that consumed fructose and a group that consumed water daily for 2 weeks. BAT activity was analyzed using thermography with cold exposure. Plasma FGF21 level was determined by enzyme-linked immunosorbent assay. Results In the cross-over single-load trial, plasma FGF21 levels were significantly increased at 2 h after oral fructose load (p < 0.01); however, there was no significant difference in BAT activity between the fructose load and drinking water. The 2-week RCT revealed that both plasma FGF21 levels and BAT activity were not significantly increased by daily fructose consumption compared to water. Correlation analyses revealed that BAT activity at the baseline and the final measurements were strongly and positively associated with the RCT (r = 0.869, p < 0.001). Changes in BAT activity were significantly and negatively correlated with changes in plasma glucose levels during the 2-week intervention (r = − 0.497, p = 0.022). Conclusions Oral fructose load induces a temporary increase in circulating FGF21 levels; however, this does not activate BAT thermogenesis in healthy young men. Further studies are needed to elucidate the effect of endogenous FGF21 on physiological function. Trial registration This study is registered with the University Hospital Medical Information Network in Japan (number 000051761, registered 1 August 2023, retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000052680
Adipose tissue · Biology · Brown adipose tissue · FGF21 · Fibroblast growth factor · Fructose · Insulin · Postprandial · Randomized controlled trial · Thermogenesis · Adipose Tissue and Metabolism · Cancer, Hypoxia, and Metabolism · Diet, Metabolism, and Disease · Medicine · Biochemistry · Endocrinology · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |