Comprehensive elucidation on the genetic profile of the Hezhou Han population via an efficient InDel panel
Bibliographic Data
| ID | 5181099 |
|---|---|
| Authors | Shuyan Mei (0000-0003-1815-8255, Henan University of Science and Technology), Wei Cui (0000-0002-3356-5054, Southern Medical University), Man Chen (0000-0002-9334-5088, Southern Medical University), Meiming Cai (Southern Medical University), Fanzhang Lei (Southern Medical University), Xi Wang (0000-0002-2434-2326, Southern Medical University), Shangwu Yang (Hezhou University, corresponding author), Bofeng Zhu (0000-0002-9038-2342, China University of Political Science and Law, corresponding author) |
| Year | 2025 |
| Volume | 10 |
| Issue | 1 |
| Pages | owae021-owae021 |
| Publication date | 2025-02-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Forensic Sciences Research (JOURNAL) |
| Journal identifiers | ISSN: 2471-1411 • E-ISSN: 2096-1790 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1093/fsr/owae021 |
| PMID | 40007634 |
| OpenAlex | W4394695666 |
| Language | EN |
| References cited | 43 |
The Han nationality is widely distributed in different regions, and it is one of the most populous nationalities in China. Compared with the ethnic minorities in Guangxi Zhuang Autonomous Region, there is relatively less research on Han individuals dwelled in Guangxi as a part of Chinese Han population. In this study, the genetic polymorphisms of 57 autosomal insertion/deletion (InDel) loci were explored in Hezhou Han (HZH) population. Forensic-related parameters revealed that these 57 InDel loci had high forensic validity and could be used in forensic practice application. In addition, the genetic relationships between the HZH population and 30 worldwide reference populations were explored using a variety of analytical methods, such as phylogenetic tree, principal component analysis, and genetic structure analysis. These results demonstrated that there were closer genetic relationships between the HZH and nine populations from East Asia (EAS). The prediction accuracy rates of five inter-continental cross-validation analyses for individuals from EAS was >0.9, and the prediction accuracy rates of three inter-continental cross-validation analyses for individuals from EAS, Europe, and Africa were all >0.95. In addition, 24 of the 57 InDel loci could be served as ancestral information inference loci, which could effectively distinguish individuals of EAS, Europe, and Africa. In conclusion, these InDel loci could be used not only as a good tool for individual identification and paternity testing in HZH population, but also as an auxiliary tool for ancestry information inference research
Allele frequency · Ancestry-informative marker · Biology · Evolutionary biology · Gene · Genotype · Indel · Inference · Population · Single-nucleotide polymorphism · Artificial Intelligence · Computer Science · Demography · Forensic and Genetic Research · Genetic diversity and population structure · Genetics · Molecular Biology Techniques and Applications
| Citation velocity | historical |
|---|---|
| Highly cited | No |