HLA Antigen Distribution in Marathi Speaking Hindu Population from Mumbai, Maharastra, India

Bibliographic Data

ID5199055
AuthorsU Shankarkumar (HLA Department, Institute of Immunohaematology (ICMR) , 13th Floor, NMS Bldg, K.E.M. Hospital, Parel, Mumbai 400 012, Maharashtra, India), V Pednakar, S V Pednakar (HLA Department, Institute of Immunohaematology (ICMR) , 13th Floor, NMS Bldg, K.E.M. Hospital, Parel, Mumbai 400 012, Maharashtra, India), Gupte, S C Gupte (ICMR - National Institute of Immunohaemotology), S Gupte (HLA Department, Institute of Immunohaematology (ICMR) , 13th Floor, NMS Bldg, K.E.M. Hospital, Parel, Mumbai 400 012, Maharashtra, India), Kanjaksha Ghosh (0000-0002-0645-6565, ICMR - National Institute of Immunohaemotology), D Mohanty (0000-0002-9790-4000, HLA Department, Institute of Immunohaematology (ICMR) , 13th Floor, NMS Bldg, K.E.M. Hospital, Parel, Mumbai 400 012, Maharashtra, India)
Year1999
Volume10
Issue5-6
Pages367-372
Publication date1999-09-01
Open AccessYes
TypeARTICLE
VenueJournal of Human Ecology (JOURNAL)
Journal identifiersISSN: 0970-9274 • E-ISSN: 2456-6608
PublisherKamla Raj Enterprises (PUBLISHER)
DOI10.1080/09709274.1999.11907514
OpenAlexW2768676874
LanguageEN
Citations received2
References cited3

Three hundred and ninety two unrelated Marathi speaking Hindu people residing in Mumbai, Maharastra. (Western India) were studied for HLA A. B and C locus antigen profiles. The phenotypic frequencies of HLA AI, A2. A9. A11, A24, A33. B5. B7. B35. B40 and Cw4 were increased while frequencies of HLA A10. A23, A28. A31. B14. B16. B18. B21. B37. B39. B50. Cwl. Cw5 and Cw8 were decreased in the Marathi speaking Hindus. The genotype frequencies of HLA A9, A24. A33 and B40 were increased while that of Al I. A28, A3I. BI5, B2I, B37, B50. Cwl 8nd Cw8 were decreased when compared with gene frequencies of other Indian Hindu populations reported Two loci haplotype analysis revealed that AI -B17. A10-B8 and A19-BI2 were common Indian Hindu haplotypes where as A3-B35. A19-BI5 and A11-B40 were unique for the Marathi Hindus Haplotype A2-B40 observed in Marathi Hindus were also observed among South Indian Hindus, while At 1 1135 have been observed among immigrant Indian Hindus. Another haplotype A3-B7 reported from both south Indian and north Indian Hindus was not observed in Marathi Hindus Significant negative linkage disequilibrium was observed for haplotypes A19-B40 and A2-B7 in Marathi Hindus. Thus the observed antigen frequencies and linkage disequilibrium in Marathi Hindus suggest the influence of genetic drift caused by selection, geography and culture. Further the study reveals that the Hindu population of India cannot be considered as a single panmietic population with reference to genetic characteristics

Antigen · Biology · Gene · Genotype · Haplotype · Hinduism · HLA-A · Human leukocyte antigen · Linkage Disequilibrium · Marathi · Population · Sociology · Demography · Immune Cell Function and Interaction · Immunotherapy and Immune Responses · Religious studies · T-cell and B-cell Immunology · Genetics

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