Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults
Bibliographic Data
| ID | 5199656 |
|---|---|
| Authors | Yoshiki Yasukochi (0000-0001-5997-959X, Kansai Medical University, corresponding author), Sora Shin (0000-0002-5486-8732, Kyushu University), Haruko Wakabayashi (0000-0003-0451-8758, Hokkaido University), Hitoshi Wakabayashi, Takafumi Maeda (0000-0001-9073-2771, Kyushu University) |
| Year | 2021 |
| Volume | 40 |
| Issue | 1 |
| Pages | 16-16 |
| Publication date | 2021-10-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of PHYSIOLOGICAL ANTHROPOLOGY (JOURNAL) |
| Journal identifiers | ISSN: 1880-6791 • E-ISSN: 1880-6805 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s40101-021-00267-9 |
| PMID | 34686211 |
| OpenAlex | W3206790774 |
| Language | EN |
| References cited | 54 |
BackgroundPhysiological thermoregulatory systems in humans have been a key factor for adaptation to local environments after their exodus from Africa, particularly, to cold environments outside Africa. Recent studies using high-throughput sequencing have identified various genes responsible for cold adaptation. However, the molecular mechanisms underlying initial thermoregulation in response to acute cold exposure remain unclear. Therefore, we investigated transcriptional profiles of six young Japanese male adults exposed to acute cold stress.MethodsIn a climatic chamber, the air temperature was maintained at 28°C for 65 min and was then gradually decreased to 19°C for 70 min. Saliva samples were obtained from the subjects at 28°C before and after 19°C cold exposure and were used for RNA sequencing.ResultsIn the cold exposure experiment, expression levels of 14 genes were significantly changed [false discovery rate (FDR) 1; thus, this gene was identified as a differentially expressed gene. Given that the cathepsin L protein is related to invasion of the novel coronavirus (SARS-CoV-2), mild cold stress might alter the susceptibility to coronavirus disease-19 in humans. The gene ontology enrichment analysis for 14 genes with FDR < 0.05 suggested that immune-related molecules could be activated by mild cold stress.ConclusionsThe results obtained from this study indicate thatCTSLexpression levels can be altered by acute mild cold stress
Biology · Downregulation and upregulation · Gene · Adipose Tissue and Metabolism · Medicine · Psychology · Thermal Regulation in Medicine · Thermoregulation and physiological responses · Genetics
Gene Ontology
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Fastp
The earliest modern humans outside Africa
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Controlling the False Discovery Rate
Rethinking the dispersal of Homo sapiens out of Africa
Testing modern human out-of-Africa dispersal models and implications for modern human origins
| Citation velocity | historical |
|---|---|
| Highly cited | No |