Sustained metabolic dysregulation and the emergence of diabetes
Associations between HbA1c and metabolic syndrome components in Tunisian diabetic and nondiabetic groups
Bibliographic Data
| ID | 5220464 |
|---|---|
| Authors | Adriana Wisniewski (0009-0002-8522-3870, University of North Carolina at Chapel Hill, corresponding author), Alicia M Delouize (0000-0002-9045-6428, University of Oregon), Tian Walker (University of Oregon), Somnath Chatterji (0000-0002-3085-6550, World Health Organization), Nirmala Naidoo (0000-0003-3186-7486, World Health Organization), Paul Kowal (0000-0002-6314-8753, University of Newcastle Australia), J Josh Snodgra (0000-0001-8877-7153, University of Oregon) |
| Year | 2024 |
| Volume | 43 |
| Issue | 1 |
| Pages | 18-18 |
| Publication date | 2024-07-20 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of PHYSIOLOGICAL ANTHROPOLOGY (JOURNAL) |
| Journal identifiers | ISSN: 1880-6791 • E-ISSN: 1880-6805 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s40101-024-00365-4 |
| PMID | 39033292 |
| OpenAlex | W4400843163 |
| Language | EN |
| Citations received | 1 |
| References cited | 46 |
Introduction Metabolic Syndrome (MetS), diabetes, and other noncommunicable diseases (NCDs) have been a major focus of research in recent decades as the prevalence of these conditions continues to rapidly increase globally. However, the timing and patterns of development from metabolic risk factors to disease states are less well understood and are especially critical to understand in low- and middle-income countries (LMICs) and populations undergoing epidemiological transitions. Methods Nationally representative sociodemographic, anthropometric, and point-of-care biomarker data from the 2016 Tunisian Health Examination Survey (n = 8170) were used to determine the prevalence of diabetes and MetS components in Tunisia and to investigate associations between glycated hemoglobin (HbA1c) and MetS components (blood pressure [BP], HDL cholesterol [HDL], triglycerides [TG], and waist circumference [WC]) in participants aged 15-97 years old. To better understand how sustained metabolic dysregulation and disease states impact these associations, diabetic and nondiabetic groups were analyzed separately. Results The overall prevalence of diabetes based on measured HbA1c was 18.2%. The diabetic groups had a higher prevalence of each individual MetS component, and significantly higher (BP, TG, WC, and HbA1c) and lower (HDL) values than the nondiabetic groups. Yet, there were a higher number of significant associations between HbA1c and MetS components found in nondiabetic women and men when compared to diabetic women and men. HbA1c was positively associated with the cumulative number of MetS components, irrespective of diabetes status in men and women. Conclusions The prevalence of both diabetes and MetS components (particularly low HDL cholesterol and elevated TG) is high among the Tunisian population. More MetS components were associated with HbA1c in nondiabetic individuals, showing a strong connection between the development of MetS components and diabetes. However, once the diabetes disease state manifests, there is more variability in the relationships. These results show the potential for HbA1c to be an indicator of metabolic health below clinical disease cutoffs, which may allow insights into the physiological changes that precipitate the emergence of diabetes
Anthropometry · Blood pressure · Diabetes mellitus · Disease · Fasting glucose · Glycated hemoglobin · Insulin resistance · Metabolic syndrome · Obesity · Type 2 diabetes · Waist · Cardiovascular Health and Risk Factors · Diabetes, Cardiovascular Risks, and Lipoproteins · Global Public Health Policies and Epidemiology · Medicine · Endocrinology · Epidemiology · Gerontology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |