Rationale for the study of the human sex ratio in population studies of polluted environments

Bibliographic Data

ID5223046
AuthorsJohn Jarrell (0000-0002-8985-8657, University of Calgary, corresponding author)
Year2002
Volume18
Issue2
Pages429-434
Publication date2002-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s0102-311x2002000200007
PMID11923884
OpenAlexW2096206987
SCIELO_PIDS0102-311X2002000200007
LanguageEN
Citations received6
References cited25

The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome

Biology · Causality (physics) · Environmental health · Identification (biology) · Infertility · Population · Pregnancy · Sex ratio · Demographic Trends and Gender Preferences · Demography · Ecology · Global Maternal and Child Health · Medicine · Migration and Labor Dynamics