Advanced maternal age and its association with placenta praevia and placental abruption
A Meta-Analysis
Bibliographic Data
| ID | 5223296 |
|---|---|
| Authors | Katrini Guidolini Martinelli (0000-0003-0894-3241, Universidade Federal do Espírito Santo, Brazil; Fundação Oswaldo Cruz, Brazil), Elena Mora García (0000-0001-9477-2383, Universidade Federal do Espírito Santo), Érica Marvila Garcia, Edson Theodoro Dos Santos Neto (0000-0002-7351-7719, Universidade Federal do Espírito Santo), Silvana Granado Nogueira Da Gama (0000-0002-9200-0387, Fundação Oswaldo Cruz) |
| Year | 2018 |
| Volume | 34 |
| Issue | 2 |
| Publication date | 2018-02-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311x00206116 |
| SCIELO_PID | S0102-311X2018000202001 |
| Language | EN |
| Citations received | 1 |
| References cited | 38 |
This study aimed to investigate the existence and magnitude of the association between advanced maternal age (AMA) and occurrence of placenta praevia (PP) and placental abruption (PA) among nulliparous and multiparous women, by a systematic review and meta-analysis. We searched articles published between January 1, 2005 and December 31, 2015, in any language, in the following databases: PubMed, Scopus, Web of Science, and LILACS. Women were grouped into two age categories: up to 34 years old and 35 years or older. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies. A meta-analysis was conducted for the PP and PA outcomes, using a meta-regression model to find possible covariates associated with heterogeneity among the studies and Egger's test to assess publication bias. The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) system (CRD42016045594). Twenty-three studies met the criteria and were included in the meta-analysis. For both outcomes, an increase in age increased the magnitude of association strength, and PP (OR = 3.16, 95%CI: 2.79-3.57) was more strongly associated with AMA than PA (OR = 1.44, 95%CI: 1.35-1.54). For parity, there was no difference between nulliparous and multiparous women considered older for the PP and PA outcomes. Our review provided very low-quality evidence for both outcomes, since it encompasses observational studies with high statistical heterogeneity, diversity of populations, no control of confounding factors in several cases, and publication bias. However, the confidence intervals were small and there is a dose-response gradient, as well as a large magnitude of effect for PP
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |