Efficacy and safety of biologics in the treatment of moderate to severe psoriasis
A Comprehensive Meta-Analysis of Randomized Controlled Trials
Bibliographic Data
| ID | 5224232 |
|---|---|
| Authors | Cassyano Januário Correr (0000-0002-4676-5266, Universidade Federal do Paraná), Inajara Rotta (Universidade Federal do Paraná), Thaís De Souza Teles (Universidade Federal do Paraná), Rangel Ray Godoy (Universidade Federal do Paraná), Bruno Salgado Riveros (0000-0002-9701-2002, Universidade Federal do Paraná), Mariana Martins Garcia (Universidade Federal do Paraná), Patrícia Rodrigues Gonçalves (Universidade Federal do Paraná), Michel Fleith Otuki (0000-0002-0159-3878, Universidade Federal do Paraná) |
| Year | 2013 |
| Volume | 29 |
| Issue | suppl 1 |
| Pages | s17-s31 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311x00157013 |
| Language | EN |
| References cited | 82 |
We conducted a systematic review and metaanalysis of randomized placebo-controlled trials in moderate-to-severe psoriasis treated with biological agents, with a follow-up of 10-14 weeks. Overall, 41 studies, with mean Jadad score of 4.4, and 15,586 patients were included. For the efficacy outcomes PASI 50, 75 and 90 our findings are not conclusive to point what biological agent has the greatest response in short term follow-up. There were no statistical differences between placebo and biologics for the occurrence of infections and serious adverse events. Ustekinumab 45mg showed lower withdrawal due to adverse events compared with the placebo. Based on data available up to now, it is not possible to determine which biological agent is the best for PASI 50, 75 or 90 after 10-14 weeks of treatment. At the same follow-up, overall safety seems to be the same for all biological agents and Ustekinumab 45mg the most well tolerated drug. To better understand efficacy and safety, indirect meta-analysis comparing drug-to-drug is required since randomized placebo-controlled trials may not be feasible
| Citation velocity | historical |
|---|---|
| Highly cited | No |