Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil

Bibliographic Data

ID5225166
AuthorsSalete Marcia Bréga (Universidade Estadual Paulista (Unesp)), Igor Vassilieff (Universidade Estadual Paulista (Unesp)), Alaor Almeida (Universidade Estadual Paulista (Unesp)), Alaor Aparecido Almeida (0000-0003-4073-8563, Universidade Estadual Paulista (Unesp)), Amauri Mercadante (Universidade Estadual Paulista (Unesp)), Denise Bissacot (Universidade Estadual Paulista (Unesp)), Denise Zuccari Bissacot (Universidade Estadual Paulista (Unesp)), Paulo R Cury (0000-0001-8907-0483, Universidade Estadual Paulista (Unesp)), Dertia V Freire-Maia (Universidade Estadual Paulista (Unesp)), D V Freire‐Maia (Universidade Estadual Paulista (Unesp))
Year1998
Volume14
Issuesuppl 3
PagesS117-S123
Publication date1998-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s0102-311x1998000700011
PMID9819469
OpenAlexW2138160059
SCIELO_PIDS0102-311X1998000700011
LanguageEN
Citations received6
References cited10

Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed. Ten non-exposed individuals were used as controls. Toxicological dosages of copper, zinc and manganese (metals found in some pesticides), hepatic enzyme dosage (GOT, GPT, AR) and acetylcholinesterase activity were performed in 16 workers and 8 controls. In the exposed workers, the most relevant clinical symptoms were poor digestion with fullness sensation after meals, irritated eyes, headache and fasciculations. The exposed group showed significantly lower manganese dosage and acetylcholinesterase activity, and significantly higher levels of alkaline phosphatase. Cytogenetic studies showed significantly higher chromosomal aberrations in the exposed group compared to the control group. Although the workers used protection against the pesticide's fog, the results revealed that the workers were contaminated with the pesticides. Therefore, the cytogenetic, toxicological studies with clinical examination are necessary for monitoring workers who are exposed to pesticides in any situation

Acetylcholinesterase · Biology · Environmental health · Enzyme · Occupational exposure · Pesticide · Biochemistry · Carcinogens and Genotoxicity Assessment · Medicine · Pesticide Exposure and Toxicity · Physiology · Toxicology

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