Behavioral effects of sub-anesthetic ketamine in a go/no-go task
Bibliographic Data
| ID | 5305233 |
|---|---|
| Authors | André Sevenius Nilsen (0000-0003-2084-6663, University of Oslo), Bjørn Erik Juel (0000-0003-0550-581X, University of Oslo), Nadine Farnes (0000-0002-1351-2254, University of Oslo), Luis Romundstad (0000-0003-0552-1668, Oslo University Hospital), Johan Frederik Storm (0000-0002-8551-4865, University of Oslo, corresponding author) |
| Year | 2021 |
| Volume | 4 |
| Issue | 3 |
| Pages | 156-162 |
| Publication date | 2021-01-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Psychedelic Studies (JOURNAL) |
| Journal identifiers | ISSN: 2559-9283 • E-ISSN: 2559-9283 |
| Publisher | Akademiai Kiado Zrt (PUBLISHER) |
| DOI | 10.1556/2054.2020.00126 |
| OpenAlex | W3127235042 |
| Language | EN |
| References cited | 22 |
Background and aimsWhile psychedelic agents are known to have powerful, but largely unexplained, effects on contents of consciousness, there is an increasing interest in the potential clinical usefulness of such drugs for therapy, and legalization is discussed in some countries. Thus, it is relevant to study the effects of psychedelic compounds not only on experience, but also on behavioral performance.MethodsSeven healthy participants performed a motor response inhibition task before, during, and after sub-anesthetic doses of intravenously administered ketamine. The infusion rate was individually adjusted to produce noticeable subjective psychedelic effects.ResultsWe observed no statistically significant impact of sub-anesthetic ketamine on reaction times, omission errors, or post error slowing, relative to the preceding drug-free condition. However, we did observe significant correlations between performance impairment and self-reported, subjective altered states of consciousness, specifically experience of "anxiety" and "complex imagery."ConclusionsConsidering the limited number of participants and large variation in strength of self-reported experiences, further studies with wider ranges of ketamine doses and behavioral tasks are needed to determine the presence and strength of potential behavioral effects
Anesthesia · Anesthetic · Anesthetic Agent · Anxiety · Consciousness · Ketamine · Psychiatry · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychedelics and Drug Studies · Psychology · Treatment of Major Depression
| Citation velocity | historical |
|---|---|
| Highly cited | No |