Dementia Entanglements in a Postgenomic Era
Bibliographic Data
| ID | 5337631 |
|---|---|
| Authors | Margaret Lock (McGill University, corresponding author) |
| Year | 2011 |
| Volume | 36 |
| Issue | 5 |
| Pages | 685-703 |
| Publication date | 2011-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Science Technology & Human Values (JOURNAL) |
| Journal identifiers | ISSN: 0162-2439 • E-ISSN: 1552-8251 |
| Publisher | SAGE Publications Inc (PUBLISHER) |
| DOI | 10.1177/0162243910388022 |
| OpenAlex | W1975898248 |
| Language | CA |
| Citations received | 12 |
| References cited | 28 |
As genetic tests become cheaper and more readily available, pressure is increasing to routinely test individuals for susceptibility genes for complex common disorders. Using Alzheimer's disease (AD) as an illustrative example, it is shown how population databases of AD cases on which individual risk estimates are based are faulty due to confusion about the AD phenotype. Furthermore, the APOEe4 genotype associated with increased risk of AD is neither necessary nor sufficient to cause AD. The article concludes with ethnographic findings that result from interviews with individuals who have been tested for their APOE status
Alzheimer's disease · Apolipoprotein E · Biology · Confusion · Dementia · Disease · Environmental health · Gene · Genotype · Pathology · Population · Alzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Genetic Associations and Epidemiology · Medicine · Psychology · Genetics
Somaticization, the making and unmaking of minded persons and the fabrication of dementia
Making Peasants Protestant and Other Projects
Anthropology and the Study of Disability Worlds
Mapping the new molecular landscape
The Evolving Classification of Dementia
Seeing a Brain Through an Other
Holding blame at bay? ‘Gene talk’ in family members’ accounts of schizophrenia aetiology
Epigenetics and aging research
Ready for What
Dementia and the Limits to Life
Postgenomics, uncertain futures, and the familiarization of susceptibility genes
The Unbound Brain - A Thematic Introduction
Genomes and What to Make of Them
The Century of the Gene
Testing Women, Testing the Fetus
Lay and professional knowledge of genetics and inheritance
Somatographic Investigations Across Levels of Complexity
(Re)Constructing Genetic Disease
Led (astray) by genetic maps
Susceptibility Genes and the Question of Embodied Identity
Eclipse of the Gene and the Return of Divination
| Unique citing works | 12 |
|---|---|
| Citations per year | 0,8 |
| Citation span | 2011 - 2022 (12) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 12 |