Systems medicine" in the view of von Bertalanffy's "organismic biology" and systems theory
Bibliographic Data
| ID | 5820148 |
|---|---|
| Authors | Felix Tretter (0000-0002-1076-1220, Bertalanffy Center for the Study of Systems Science Vienna Austria, corresponding author) |
| Year | 2019 |
| Volume | 36 |
| Issue | 3 |
| Pages | 346-362 |
| Publication date | 2019-05-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Systems Research and Behavioral Science (JOURNAL) |
| Journal identifiers | ISSN: 1092-7026 • E-ISSN: 1099-1743 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/sres.2588 |
| OpenAlex | W2946070794 |
| Language | EN |
| Citations received | 3 |
| References cited | 57 |
Currently, medicine is transforming towards molecular systems medicine (MSM), based on molecular systems biology (MSB). These approaches should be related to Ludwig von Bertalanffy's vision of "organismic" systems biology/medicine (OSB/OSM) and of general system theory (GST), which he created already in the 1930s. In this paper, on the basis of current diversity of knowledge in medicine, major differences between MSB/MSM and OSB/OSM are highlighted: MSB is based on biochemical high-throughput technologies, sophisticated mathematical data analytical tools, and supercomputers for computation, whereas OSB is based on developmental biology and is concept and theory oriented. Metatheoretical considerations show that holistic but still reductive MSM cannot bridge the categorical molecule-cell difference, the mind-body difference, and the environment-organism gap by a consistent molecular and mechanistic theory of the organism. In contrast, the options of theoretical interlevel modelling with the help of simply structured but complexly functioning organ models are discussed here. As example, the neurochemical mobile of the brain is discussed. Consequently, a reconsideration of GST in medicine, targeting OSM, seems to be fruitful by linking MSM with a core concept of a systems pathology and with psychosocial and clinical medicine
Categorical variable · Systems medicine · Systems theory · Bioinformatics and Genomic Networks · Gene Regulatory Network Analysis · Microbial Metabolic Engineering and Bioproduction
What Functions Explain
Everything Flows
The Origins of Order
Ecology of the Brain
Network medicine
The Prevalence of Comorbid Depression in Adults With Diabetes
What Mary Didn't Know
Das Reafferenzprinzip
The Extended Mind
The Need for a New Medical Model
The Positivist dispute in German sociology
Explanation
Reducing mind to molecular pathways
What Is It Like to Be a Bat
An Outline of General System Theory
Medical Philosophy
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,6 |
| Citation span | 2021 - 2026 (6) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |