Relações entre ocitocina, apego e sono em pessoas com Transtorno de Ansiedade Generalizada

Bibliographic Data

ID5833764
AuthorsEliana Araujo Nogueira Do Vale (corresponding author)
Year2019
Publication date2019-08-28
Peer ReviewedYes
Open AccessYes
TypeTHESIS
PublisherUniversidade de São Paulo. Agência de Bibliotecas e Coleções Digitais (PUBLISHER)
DOI10.11606/t.47.2019.tde-16082019-110304
OpenAlexW2970004262
LanguagePT
References cited14

Introduction:In Generalized Anxiety Disorder [GAD] there is a prevalence of simptoms of anxiety, insomnia, irritability, persistent nervousness, trembling, muscle tension, palpitations, dizziness and epigastric discomfort, causing malaise and an imbalance in homeostasis.In humans and other mammals, babies and pups calm down upon receiving maternal care, as a result of the regulatory action of attachment behavior associated to the release of neuropeptide oxytocin [OT].Falling asleep is probably eased as a consequence of attenuation of excitatory states.This associated action also favors the creation of a strong, long-lasting love bond, as well as states of well-being and calm in the motherbaby dyad.Objectives: To investigate eventual relations between OT, attachment and psychophysiological and homeostatic aspects of sleep-insomnia in patients with GAD.Hypothesis: After intervention (administration of IN OT or saline), GE should present, in relation to GP, a state of calm and well-being, characterized by a decrease in salivary cortisol levels, in anxiety, and improvement in positive and negative affects [oxytocinergic regulation], favoring, as a consequence, the process of falling asleep.Design: Translational Research in Neurosciences, with N = 27 male adults diagnosed with GAD, randomized in experimental [EG] and placebo group [PG].Materials & Methods: Initial and final interviews; sociodemographic data, scales of attachment, anxiety and positive & negative affects; and sleep diary.After randomization, EG and PG were administered, in a double-blind way, respectively, intranasal OT spray and saline spray, twice a day, for four weeks, with assessment of salivary cortisol, anxiety and affects, before and after intervention.Results: When compared with baseline, final results showed a decrease in salivary cortisol levels, an improvement in anxiety as well as in affects in GE in relation to GP.Both groups presented a decrease in average sleep hours; however, GE had a qualitative improvement in sleep quality.Both groups presented a similar attachment profile, with higher levels of Overprotection when compared with Care, both maternal and paternal, and prevalence of the Affective Controltype bond.Conclusions: Results indicate that experimental and placebo interventions were associated with higher rates of positive affects, and lower rates of negative affects, anxiety, and salivary cortisol in both groups, however, in the EG these results were more accentuated, as well as qualitatively associated with improvement in mood, social relations, and sleep quality.As for attachment, results suggest that the participants probably received more control and overprotection than loving care from their parental environment

Anxiety · Generalized anxiety disorder · Irritability · Psychiatry · Child and Adolescent Psychosocial and Emotional Development · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroendocrine regulation and behavior · Psychology · Internal Medicine

Tools

Open DOIOpen Access