Sociodemographic patterns in biomarkers of aging in the Add Health cohort
Bibliographic Data
| ID | 5958043 |
|---|---|
| Authors | Jennifer Momkus (0000-0002-8905-4878, University of North Carolina at Chapel Hill, corresponding author), A E Aiello (0000-0001-7029-2537, Columbia University), Rebecca Stebbins (0000-0002-3663-1360, Columbia University), Y S Zhang (0000-0002-1290-9305, Columbia University), Kathleen Mullan Harris (0000-0001-9757-1026, University of North Carolina at Chapel Hill) |
| Year | 2024 |
| Volume | 69 |
| Issue | 2 |
| Pages | 57-74 |
| Publication date | 2024-04-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Biodemography and Social Biology (JOURNAL) |
| Journal identifiers | ISSN: 1948-5565 • E-ISSN: 1948-5573 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/19485565.2024.2334687 |
| PMID | 38551453 |
| OpenAlex | W4393307943 |
| Language | EN |
| Citations received | 2 |
| References cited | 57 |
Biomarkers in population health research serve as indicators of incremental physiological deterioration and contribute to our understanding of mechanisms through which social disparities in health unfold over time. Yet, few population-based studies incorporate biomarkers of aging in early midlife, when disease risks may emerge and progress across the life course. We describe the distributions of several biomarkers of inflammation and neurodegeneration and their variation by sociodemographic characteristics using blood samples collected during Wave V of the National Longitudinal Study of Adolescent to Adult Health (ages 33-44 years). Higher mean levels of inflammatory and neurodegenerative biomarkers were associated with greater socioeconomic disadvantage. For example, the neurodegenerative markers, Neurofilament Light Chain and total Tau proteins were higher among lower income groups, though the relationship was not statistically significant. Similarly, proinflammatory marker Tumor Necrosis Factor-α (TNF-α) levels were higher among those with lower education. Significant differences in the mean levels of other proinflammatory markers were observed by race/ethnicity, sex, census region, BMI, and smoking status. These descriptive findings indicate that disparities in biomarkers associated with aging are already evident among young adults in their 30s and attention should focus on age-related disease risk earlier in the life course
Cohort · Developmental psychology · Disease · Environmental health · Ethnic group · Inflammation · Life course approach · Population · Proinflammatory cytokine · Socioeconomic status · Adipokines, Inflammation, and Metabolic Diseases · Birth, Development, and Health · Demography · IL-33, ST2, and ILC Pathways · Medicine · Psychology · Gerontology · Internal Medicine
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| Unique citing works | 2 |
|---|---|
| Citations per year | 2 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |