The Influence of Mexidol on Morphological Changes in the Structure of the Liver of Rats After Chronic Bankol Intoxication
Bibliographic Data
| ID | 5967467 |
|---|---|
| Authors | Yu D Lyashev (0000-0003-0536-923X, Kursk State Medical University), A Korolev, Vladimir A Korolev (0000-0002-4376-4284, Kursk State Medical University), N E Kirishcheva (Kursk State Medical University), N Ryzhaeva, V N Ryzhaeva (Kursk State Medical University) |
| Year | 2015 |
| Volume | 22 |
| Issue | 12 |
| Pages | 38-41 |
| Publication date | 2015-12-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Ekologiya Cheloveka (Human Ecology (JOURNAL) |
| Journal identifiers | ISSN: 1728-0869 • E-ISSN: 2949-1444 |
| Publisher | ECO-Vector LLC (PUBLISHER • RU) |
| DOI | 10.17816/humeco16964 |
| OpenAlex | W4302388020 |
| Language | EN |
| Citations received | 1 |
| References cited | 2 |
It has been established, that modeling of acute or chronic bankol intoxication in Vistar rats was accompanied by apparent structural changes in the liver tissue, that manifested in the increased proportion of necrotizing and burned-out tissues, widening of the intrahepatic sinuses, stroma edema, the increased number of binuclear cells. Use of mexidol during chronic bankol injections caused a decrease in the proportion of necrotizing and burned-out tissues by 1.68 times (p = 0.0003) as well as intensification of reparative processes by 2.02 times (p = 0.0004), that manifested in the increased number of binuclear cells and the number of cells, in which nuclei there were two or more nucleoli
Edema · Immunohistochemistry · Liver tissue · Nucleolus · Pathology · Stroma · Drug-Induced Hepatotoxicity and Protection · Eicosanoids and Hypertension Pharmacology · Liver Disease Diagnosis and Treatment · Medicine · Internal Medicine
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |