Intestinal Microbiota and Oxidative Stress in Patients With Metabolic Syndrome
Bibliographic Data
| ID | 5967933 |
|---|---|
| Authors | I I Shantir, G G Rodionov, Г Г Родионов (0000-0001-6237-7848, Ministry of Emergency Situations), Yu A Fominykh (0000-0002-2436-3813, First Pavlov State Medical University of St. Petersburg), Batskov, С С Бацков (Ministry of Emergency Situations), I E Ushal, И Э Ушал (0000-0001-5857-3627, Ministry of Emergency Situations), E A Kolobova, Е А Колобова (0000-0001-6369-4511, Ministry of Emergency Situations), E V Svetkina, Е В Светкина (0000-0001-9540-5980, Ministry of Emergency Situations), Maksim V Sannikov (0000-0003-3969-9501, Ministry of Emergency Situations) |
| Year | 2019 |
| Volume | 26 |
| Issue | 6 |
| Pages | 23-29 |
| Publication date | 2019-06-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Ekologiya Cheloveka (Human Ecology (JOURNAL) |
| Journal identifiers | ISSN: 1728-0869 • E-ISSN: 2949-1444 |
| Publisher | ECO-Vector LLC (PUBLISHER • RU) |
| DOI | 10.33396/1728-0869-2019-6-23-29 |
| OpenAlex | W2953266162 |
| Language | EN |
| References cited | 11 |
Aim: To study intestinal microbiota and the parameters of oxidative stress in patients with metabolic syndrome (MS). Methods: The sample consisted of 50 patients with MS aged 55-65 years and residing in Saint Petersburg. The reference group consisted of 129 individuals of similar age without MS. The quantitative and qualitative composition of parietal intestinal microbiota was studied by gas chromatography with mass spectrometry using microbial markers in plasma. Oxidative stress the final oxidation products of protein molecules and lipids including 8-hydroxy-2-deoxyguanosine and malonic aldehyde were estimated. Nutritional antioxidants including vitamin E, unsaturated fatty acids etc. were assessed by chromatography mass spectrometry and mass spectrometry. Results: In the parietal layer of the intestine in individuals with MS, the total number of microbial markers is positively associated with the markers of the opportunistic microflora and lower levels of normal microflora. In MS patients, the ratio of normal microflora to conditionally pathogenic microflora is twice as low as in the reference group. Level of malonic dialdehyde and 8-hydroxy-2-deoxyguanosin were 48 % and 39 % higher in the MS group. Moreover, plasma concentrations of vitamin E and zinc were lower by 42 % and 80 % in patients with MS compared to the reference group. Сonclusions: The observed differences in the quantitative and qualitative composition of the parietal microbiota of the intestine in individuals with MS compared to the reference group suggest development of intestinal dysbiosis in MS patients. The intestinal dysbiosis is accompanied by oxidative stress manifested by an increase in the level of malonic dialdehyde in the blood plasma and 8-hydroxy-2-deoxyguanosine in the urine, as well as a decrease in the level of vitamin E and zinc in the blood plasma
Biology · Dysbiosis · Gut flora · Oxidative stress · Chemistry · Diet and metabolism studies · Diet, Metabolism, and Disease · Gut microbiota and health · Medicine · Biochemistry · Endocrinology · Internal Medicine · Physiology
| Highly cited | No |
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