Imbalance of Barium, Strontium, and Manganese Levels in the Human Body in Breast Cancer
Bibliographic Data
| ID | 5968320 |
|---|---|
| Authors | Elena A Sarf (0000-0003-4918-6937, Omsk State Pedagogical University), Lyudmila V Bel''Skaya (0000-0002-6147-4854, Omsk State Pedagogical University) |
| Year | 2025 |
| Volume | 32 |
| Issue | 3 |
| Pages | 172-181 |
| Publication date | 2025-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Ekologiya Cheloveka (Human Ecology (JOURNAL) |
| Journal identifiers | ISSN: 1728-0869 • E-ISSN: 2949-1444 |
| Publisher | ECO-Vector LLC (PUBLISHER • RU) |
| DOI | 10.17816/humeco678136 |
| OpenAlex | W4412831243 |
| Language | EN |
| References cited | 26 |
BACKGROUND: Among the multifactorial nature of environmental pollution, one of the significant concerns is the impact of heavy metals, as their imbalance in the body is potentially hazardous, and elevated concentrations may lead to the development of serious diseases, including cancer.AIM: The work aimed to analyze the association between salivary levels of heavy metals (strontium, manganese, and barium) and occupational conditions, as well as the presence of cancer, using breast cancer as a model.METHODS: A single-center, cross-sectional, observational study was conducted. Inclusion criteria for the main study group included female sex; age 30-70 years; confirmed diagnosis of invasive breast cancer (subgroup 1) or benign breast disease (subgroup 2); no prior treatment at the time of study, including surgery, chemotherapy, or radiotherapy; absence of signs of active infection, including purulent processes; and completed oral cavity sanitation. The inclusion criteria: healthy women without occupational hazards for the control group, and women working at a thermal power plant for the comparison group. The concentrations of strontium, barium, and manganese in saliva were determined in all women using capillary electrophoresis.RESULTS: Subgroup 1 of the main group included 110 patients with breast cancer (mean age 58.4±9.38 years). Subgroup 2 comprised 62 patients with fibroadenoma (46.7 ± 13 years). The control group consisted of 97 healthy women (48.2±7.95 years), and the comparison group included 41 women employed at a thermal power plant (47.5±9.88 years). Elevated salivary levels of strontium and manganese were observed in subgroup 1. Manganese levels were significantly higher in subgroup 1 compared with the control group (+117%, p=0.045) and the comparison group (+105.2%). Strontium was not detected in the saliva of the control group, whereas its concentration in subgroup 1 was 3.5 times higher than in the comparison group (p 0.001). No significant differences in barium levels were found between the groups. A significant increase in salivary manganese and strontium concentrations was observed with advancing stage and aggressiveness of breast cancer.CONCLUSION: Comparison with saliva samples from women exposed to occupational hazards suggests that the source of heavy metal accumulation is not environmental exposure but an internal imbalance of trace elements. Consequently, salivary accumulation of strontium and manganese appears to be associated with breast cancer progression
Barium · Breast cancer · Cancer · Manganese · Metallurgy · Strontium · Chemistry · Heavy Metal Exposure and Toxicity · Materials Science · Medicine · Oral health in cancer treatment · Salivary Gland Disorders and Functions · Cancer Research · Inorganic Chemistry · Internal Medicine
Medical and Ecological Aspects of Associations Between Human Exposure to Trace Concentrations of Stable Barium and Strontium and Functional Disorders of the Body. A Review
Cell Death Under Conditions of Haptic Contamination of Biological Media by Stable Strontium
Determination of the macro- and microelement composition of the saliva of СHPP workers
| Highly cited | No |
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