Assessment of the Role of Selected Comorbidities on Overall -and Cardiovascular Mortality in Southern Kazakhstan

A 12-Years Follow-Up Study

Datos Bibliográficos

ID5968342
AutoresA D Sadykova, Assel Sadykova (0000-0002-4662-0817, Ahmet Yesevi University), Zh S Shalkharova (Ahmet Yesevi University), Zh N Shalkharova, Ж Н Шалхарова (Ahmet Yesevi University), I Ibragimova, Sarviniso Islamovna Ibragimova (0000-0002-2295-672X, Ahmet Yesevi University), Dilorom Kamilzhanovna Ibragimova (Ahmet Yesevi University), E G Saruarov, Е Г Саруаров (Ahmet Yesevi University), Gulshad Gafurxanovna Sharabitdinova (Ahmet Yesevi University), Dilfuza Narzullaevna Mamraimova (Ahmet Yesevi University), V Ivanov, С В Иванов (0000-0001-9532-7150, First Pavlov State Medical University of St. Petersburg), A M Grjibovski, Andrej М Grjibovski (0000-0002-5464-0498, North-Eastern Federal University)
Año2016
Volumen23
Número11
Páginas42-49
Fecha de publicación2016-11-15
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaEkologiya Cheloveka (Human Ecology (JOURNAL)
Identificadores de la revistaISSN: 1728-0869 • E-ISSN: 2949-1444
EditorialECO-Vector LLC (PUBLISHER • RU)
DOI10.33396/1728-0869-2016-11-42-49
OpenAlexW2967154847
IdiomaEN
Citas recibidas1
Referencias citadas12

The aim of the study was to assess survival of patients with isolated and combined disorders of circulatory system and diabetes mellitus in Turkestan region, Southern Kazakhstan. Altogether, 1 143 randomly selected individuals comprised a cohort, which was followed up from 2003 through 2015. Data on diagnosis, age, gender, body mass index, smoking and alcohol consumption were collected by trained medical interviewers. Bivariate comparisons of survival between groups with no cardiovascular diseases and groups with isolated and combined disorders were performed using Kaplan-Meier analysis. Independent associations between the studied factors and overall mortality as well as mortality from cardiovascular causes were assessed using Cox regression. Crude and adjusted hazard ratios (HR) were calculated with 95 % confidence intervals (CI). The overall mortality in the cohort was 145 per 1 000 with cardiovascular causes accounting for 49 % of deaths during the study period. The risk of death from any cause was increased for individuals who had arterial hypertension and diabetes mellitus (HR = 4.6, 95 % CI: 1.4-15.3) and combined arterial hypertension, cardiac ischemia and diabetes mellitus (HR = 7.0, 95 % CI: 2.1-26.1) in fully adjusted Cox regression model. The risk of cardiovascular death was increased among patients with isolated cardiac ischemia (HR = 2.7, 95 % CI: 1.1-6.8) and among those with combined arterial hypertension and diabetes mellitus (HR = 8.7, 95 % CI: 2.5-30.4) adjusted for gender, age, smoke, alcohol consumption and body mass index. Combined disorders of circulatory system and diabetes mellitus considerably increase the risk of death in Turkestan region, Southern Kazakhstan warranting urgent need for evidence-based treatment of comorbidities and development of preventive programs

Body mass index · Cardiology · Cohort · Cohort study · Confidence interval · Diabetes mellitus · Hazard ratio · National Death Index · Proportional hazards model · Chronic Disease Management Strategies · Health Promotion and Cardiovascular Prevention · Healthcare Systems and Public Health · Medicine · Endocrinology · Internal Medicine