Associations Between Periodontal Microbiota and Metabolic Markers Among the Nenets in Arctic Russia

Introduction: Classical risk factors do not fully explain the development of cardiovascular diseases, diabetes mellitus and metabolic syndrome. Recent studies have reported associations between periodontal diseases and metabolic disturbances, although the data from Russia is scarce. Aim: To study associations between the periodontal microbiota and the main markers of metabolism among the Nenets permanently living on the Vaygach island, Arctic Russia. Methods: Oral hygiene, intensity of gingival inflammation, DNA of the main periodontal pathogens and blood concentrations of cholesterol, triglycerides, glucose and lactate were assessed in 48 individuals. Mann-Whitney tests, correlation analysis and multivariable logistic regression analysis were used to study associations between the studies variables Results: Oral hygiene in the examined subjects was good - 1,0 (0.3; 1.0), and there was little inflammation in the gum tissues - 0.0 % (0.0; 15.0). In 54.2 % of the study participants no periodontal pathogens with clinically relevant concentrations were detected while in 45.8 % from 1 to 5 periodontal pathogens at a clinically relevant concentration were found. The total cholesterol rate in blood serum was 5.1 (4.5; 5.9) mmol/L, triglycerides 1,3 (1.1; 2.7) mmol/L, glucose 4,9 (4.2; 5.4) and lactate 4.8 (3.8; 6.0). Positive correlation was observed between total cholesterol and the OHI-S score (rs = 0.681, p = 0.003). No other associations were found. Conclusions: Complex associations between periodontal microbiota and metabolic markers described in the literature warrant further research in Arctic settings aimed at identifying additional triggers for the development of vascular events

Diabetes mellitus · Gingival and periodontal pocket · Logistic regression · Metabolic syndrome · Oral hygiene · Periodontitis · Dental Health and Care Utilization · Dentistry · Medicine · Oral microbiology and periodontitis research · Salivary Gland Disorders and Functions · Endocrinology · Gastroenterology · Internal Medicine · Physiology