Paternal HLA Genotype and Offspring Sex Ratio
Bibliographic Data
| ID | 6068503 |
|---|---|
| Authors | Paola Astolfi (0000-0003-3226-082X, University of Pavia), M Cuccia (University of Pavia), M Martinetti (Istituti di Ricovero e Cura a Carattere Scientifico) |
| Year | 2001 |
| Volume | 73 |
| Issue | 2 |
| Pages | 315-319 |
| Publication date | 2001-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Publisher | Project MUSE (PUBLISHER • US) |
| DOI | 10.1353/hub.2001.0015 |
| PMID | 11446432 |
| OpenAlex | W2073280198 |
| Language | EN |
| Citations received | 5 |
For twenty years, W.H. James has been proposing that the sex hormone level of both parents could control at least a quota of the secondary sex ratio variation at the time of conception. Observations supporting this hypothesis have come from investigations on some diseases related to the human leukocyte antigen (HLA). In the present study on 1102 healthy Italian families, we investigated the potential effect on the offspring sex ratio of HLA-B alleles on the basis of a genetic model. We defined three subsets of HLA-B alleles and hypothesized a locus (L) with three alleles, L(H), L(N), L(B15), on the basis of the positive, neutral, or negative effect on the testosterone level. According to the genetic model and the dominance relation L(H) > L(B15) > L(N), six genotypic and three phenotypic classes (H, N, B15) can be expected. We found a significantly high number of daughters (66%) born to fathers carrying the B15 phenotype. This result suggests an effect of the HLA-B15 allele on the secondary sex ratio, mediated by a low testosterone level
Allele · Antigen · Biology · Dominance (genetics · Gene · Genotype · Human leukocyte antigen · Locus (genetics · Offspring · Phenotype · Population · Pregnancy · Sex ratio · Demographic Trends and Gender Preferences · Demography · Genetics · Global Maternal and Child Health · Intergenerational Family Dynamics and Caregiving
Abo Blood Groups and Completed Reproductive Performance of Rural Haryanavi Couples
Variation of Human Sex Ratios at Birth by the Sex Combinations of the Existing Sibs, and by Reproductive Stopping Rules
The Categories of Evidence Relating to the Hypothesis That Mammalian Sex Ratios at Birth Are Causally Related to the Hormone Concentrations of Both Parents Around the Time of Conception
Variation of the Probability of a Male Birth Within and between Sibships
On the Adaptively Biassed Offspring Sex Ratios of Hungarian Gypsies
| Citations per year | 0.22 |
|---|---|
| Citation span | 2003 - 2011 (9) |
| Highly cited | No |