Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

Bibliographic Data

ID6157758
AuthorsYun Ho Choi (Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.), Eui Hyeog Han (Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.), Ok Hee Chai (0000-0003-2889-9743, Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.), Yun Kyu Kim (0000-0002-8403-945X, Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.), Hyoung Tae Kim (Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.), Chang Ho Song (0000-0001-6444-619X, Department of Anatomy, Chonbuk National University Medical School, Jeonju, Korea.)
Year2010
Volume23
Issue4
Pages217-217
Publication date2010-01-01
Open AccessNo
TypeARTICLE
VenueKorean Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 1225-150X • E-ISSN: 2287-626X
PublisherKorean Association of Physical Anthropologists (PUBLISHER)
DOI10.11637/kjpa.2010.23.4.217
OpenAlexW1903431418
LanguageEN
Citations received1
References cited2

Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic diseases. Scutellaria baicalensis is a widely used herb in traditional oriental medicine with anticancer, antiviral, antibacterial and anti-inflammatory properties. However, the roles of Scutellaria baicalensis in mast cell-mediated anaphylactic reactions have not fully been investigated. In this study, we examined the influences of the methanol extract of Scutellaria baicalensis (MESB) on compound 48/80- or anti-dinitrophenyl (DNP) IgE-induced anaphylaxis-like response in vivo. To further prove these in vivo results, the inhibitory effect of MESB on mast cell activation was evaluated, focusing on the histamine release from rat peritoneal mast cells (RPMC). MESB inhibited compound 48/80-induced systemic anaphylaxis-like reaction, plasma histamine release and ear swelling response in mice. MESB also attenuated passive systemic and cutaneous anaphylaxis evoked by anti-DNP IgE. In in vitro experiments, MESB dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, compound 48/80-elicited calcium uptake was suppressed in a concentration-dependent manner of MESB. Furthermore, MESB transiently increased the level of intracellular cAMP. From these results, it is suggested that MESB possesses effective anti-anaphylactic activity

Allergy · Anaphylaxis · Antibody · Baicalein · Biology · Compound 48/80 · Degranulation · Histamine · Immunoglobulin E · In vivo · Mast cell · Pathology · Receptor · Scutellaria baicalensis · Traditional Chinese medicine · Chemistry · Flavonoids in Medical Research · Mast cells and histamine · Medicinal plant effects and applications · Medicine · Biochemistry · Immunology · Pharmacology

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