Immune recovery after antiretroviral therapy initiation
A challenge for people living with HIV in Brazil
Bibliographic Data
| ID | 7695154 |
|---|---|
| Authors | Cássia C P Mendicino (0000-0002-1627-292X, Universidade Federal de Minas Gerais), Erica E M Moodie (0000-0002-7225-3977, McGill University), Mark Drew Crosland Guimarães (0000-0001-7932-3854, Universidade Federal de Minas Gerais), Cristiane A Menezes De Pádua (0000-0001-7083-3188, Universidade Federal de Minas Gerais) |
| Year | 2021 |
| Volume | 37 |
| Issue | 9 |
| Pages | e00143520-e00143520 |
| Publication date | 2021-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/0102-311x00143520 |
| PMID | 34669770 |
| OpenAlex | W3205779747 |
| SCIELO_PID | S0102-311X2021000905009 |
| Language | EN |
| Citations received | 1 |
| References cited | 32 |
Immune recovery reflects health conditions. Our goal was to estimate the time it takes to achieve immune recovery and its associated factors, in people living with HIV (PLHIV), after antiretroviral therapy (ART) initiation. A historical cohort study was performed among PLHIV (> 18 years-old) in Minas Gerais State, Brazil, using data from healthcare databases. Patients initiating ART between 2009-2018, with T-CD4+ lymphocytes and viral load recorded before and after antiretroviral therapy were included. The outcome is achievement of immune recovery, defined as the first T-CD4+ > 500 cells/μL after ART initiation. Explanatory variables were age, gender, place of residence, year of ART initiation, baseline viral load and T-CD4+, viral load status, and adherence to ART at follow-up. Descriptive analysis, cumulative, and person-time incidences of immune recovery were estimated. Median-time to immune recovery was estimated using Kaplan-Meier method. Factors associated with immune recovery were assessed by Cox regression. Among 26,430 PLHIV, 8,014 (30%) were eligible. Most were male (67%), mean age 38.7 years, resided in non-central region, median-baseline T-CD4+ = 228 cells/μL ( 200 cells/μL, detectable viral load (baseline), antiretroviral therapy-adherence and undetectable viral load (follow-up) were independently associated with immune recovery. Time to immune recovery remains long and depends on early treatment and antiretroviral therapy-adherence
Antiretroviral therapy · Cohort · Cohort study · Cumulative incidence · Human immunodeficiency virus (HIV) · Immune system · Proportional hazards model · Residence · Viral load · Demography · HIV Research and Treatment · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Immunology · Internal Medicine · Medicine · Gerontology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |