Apolipoprotein H Genetic Variability in the Population of Krk Island, Croatia

Bibliographic Data

ID7990333
AuthorsKsenija Vitale (0000-0002-9842-8122, Andrija Stampar Teaching Institute of Public Health), Milica Trbojević-Čepe, Nina Smolej‐Narančić, Nina Smolej-Narancic
Year2002
Volume74
Issue4
Pages545-554
Publication date2002-01-01
Open AccessNo
TypeARTICLE
VenueHuman Biology (JOURNAL)
Journal identifiersISSN: 0018-7143 • E-ISSN: 1534-6617
PublisherProject MUSE (PUBLISHER • US)
DOI10.1353/hub.2002.0049
PMID12371681
OpenAlexW1981241441
LanguageEN
Citations received1
References cited6

Apolipoprotein polymorphisms are emerging as suitable markers for the study of the formation of human populations. In contrast to the data available for apolipoprotein E, the data regarding apolipoprotein H (protein, apoH; gene, APOH) variations are only beginning to accumulate. By blood plasma isoelectric focusing and immunoblotting, we analyzed the distribution of apoH phenotypes in 397 individuals (192 males; 205 females) from seven villages of an autochthonous population of the eastern Adriatic island of Krk. APOH allele frequencies were: APOH*2 = 0.877, APOH*3 = 0.098, APOH*1 = 0.025, with the majority of the sample being homozygous. No significant differences between villages were observed. When these data were compared to those of other populations studied so far, a significant association between APOH allele frequencies and latitude was observed. We hypothesize that this association reflects differences in diet composition across different climatic zones

Allele · Apolipoprotein B · Biology · Cholesterol · Gene · Population · Sociology · Adipokines, Inflammation, and Metabolic Diseases · Demography · Diabetes, Cardiovascular Risks, and Lipoproteins · Endocrinology · Genetic Associations and Epidemiology · Genetics

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