A New Era in Democratic Portugal? The 2009 European, Legislative and Local Elections
Bibliographic Data
| ID | 8020722 |
|---|---|
| Authors | André Freire (0000-0001-5307-6832, corresponding author) |
| Year | 2010 |
| Volume | 15 |
| Issue | 4 |
| Pages | 593-613 |
| Publication date | 2010-12-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | South European Society & Politics (JOURNAL) |
| Journal identifiers | ISSN: 1360-8746 • E-ISSN: 1743-9612 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1080/13608746.2010.521637 |
| OpenAlex | W2144766141 |
| Language | EN |
| Citations received | 15 |
| References cited | 3 |
The reduction of neutrophil migration to an infectious focus is associated with a high mortality in severe sepsis. Previously, we showed that heme oxygenase (HO) products downregulate neutrophil recruitment in a noninfectious inflammatory model. The present study was designed to determine the role of HO in sepsis induced by cecal ligation and puncture (CLP) model. We demonstrated that pretreatment, but not the combination of pretreatment plus posttreatment with zinc protoporphyrin IX (ZnPP IX), an HO inhibitor, prevented the reduction of CXCR2 on circulating neutrophils and the failure of intraperitoneal neutrophil migration to the site of infection. Consequently, bacterial dissemination, systemic inflammatory response, and organ injury were prevented. In addition, pretreatment with the HO inhibitor avoided hypotension and consequently increased survival. Moreover, in mice subjected to severe CLP, the pretreatment, but not the combination of pretreatment plus posttreatment with ZnPP IX, prevented the increase of plasmatic free heme observed in nontreated severe CLP. The administration of exogenous hemin to mice subjected to moderate sepsis consistently increased the mortality rate. Furthermore, hemin resulted in a reduction of neutrophil migration both in vivo and in vitro. Altogether, our results demonstrated that pretreatment with the HO inhibitor prevents the pathological findings in severe CLP. However, the combination of pretreatment plus posttreatment with ZnPP IX enhances sepsis severity because of an increase in circulating levels of heme, which is deleterious to the host tissues and also inhibits neutrophil migration
Democracy · Democratic system · Economics · Electoral system · General election · Legislature · Political economy · Political science · Politics · Portuguese · European Union Policy and Governance · Law · Political Systems and Governance · Public Administration · Social Policy and Reform Studies
Hungary – A Hungarian Crisis or Just a Crisis in Hungary?
Conclusion
Ireland – Limited Restructuration in the Poster Child of Austerity
European Party Politics in Times of Crisis
Spain – Out with the Old
Portugal – A Tale of Apparent Stability and Surreptitious Transformation
The Elections of the Great Recession in Portugal
Crises and the Transformation of the National Political Space in Europe
Regional elections in Portugal
The 2024 European Parliament elections in Portugal
Local Elections and the Turkish Voter
After the Bailout
Trust across political conflicts
Economic voting in Portugal, 2002-2009
Do parties respond strategically to opinion polls? Evidence from campaign statements
| Unique citing works | 15 |
|---|---|
| Citations per year | 1,07 |
| Citation span | 2012 - 2025 (14) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 15 |