The Variable Expression of the C 4/5 Complex of Human Butyrylcholinesterase and Body Mass Index
Bibliographic Data
| ID | 8052295 |
|---|---|
| Authors | Vânia M Alcântara, Luciane C Rodrigues, Lisângela Cristina de Oliveira (0000-0001-8533-1252), Eleidi A Chautard-Freire-Maia, Eleidi A Chautard‐freire‐maia |
| Year | 2003 |
| Volume | 75 |
| Issue | 1 |
| Pages | 47-55 |
| Publication date | 2003-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Publisher | Project MUSE (PUBLISHER • US) |
| DOI | 10.1353/hub.2003.0015 |
| PMID | 12713145 |
| OpenAlex | W2031104697 |
| Language | EN |
| Citations received | 1 |
| References cited | 1 |
The activity of a supposedly heteromeric complex (C4/5) of butyrylcholinesterase (BChE; EC 3.1.1.8) was analyzed in relation to body mass index (BMI). The activities of the C4/5 and C(OF) (other molecular forms) bands in CHE2 C5- (n = 447) and CHE2 C5+ (n = 88) individuals were quantified by densitometry. Since the absolute activity of C4/5 (AC4/5) showed the highest correlation coefficient with weight in the CHE2 C5- phenotype when compared to the other BChE activity variables (total, relative C4/5, and absolute C(OF)), this variable was used for the classification of 51 CHE2 C5-individuals into three groups (low, average, and high), paired by sex, age, and ethnic origin. The low AC4/5 group was found to present a significantly (p < 0.0001) lower mean BMI (22.9) than the other groups (average = 25.2, and high = 26.3). In the CHE2 C5+ individuals no statistically significant standardized regression coefficient was verified between BMI (dependent variable) and the C4/5, band activities. These data show that the behavior of the C4/5 band in relation to BMI differs between the CHE2 C5- and CHE2 C5+ phenotypes. While the C5 band of the CHE2 C5+ individuals is negatively associated with fat storage in the adipose cells, the present data show that the C4/5 band is positively associated with this storage in the CHE2 C5- phenotype
Body mass index · Butyrylcholinesterase · Chromatography · Coefficient of variation · Correlation coefficient · Densitometry · Enzyme · Gene · Linear regression · Phenotype · Statistics · Chemistry · Cholinesterase and Neurodegenerative Diseases · Computational Drug Discovery Methods · Mathematics · Medicine · Pesticide Exposure and Toxicity · Biochemistry · Internal Medicine
| Citations per year | 0.05 |
|---|---|
| Citation span | 2005 - 2005 (1) |
| Highly cited | No |