Dramatic founder effects in Amerindian mitochondrial DNAs
Bibliographic Data
| ID | 8312232 |
|---|---|
| Authors | Douglas C Wallace (0000-0002-7480-8278, Emory University), Katherine Garrison (Emory University), William C Knowler (0000-0002-7004-5197, National Institute of Diabetes and Digestive and Kidney Diseases) |
| Year | 1985 |
| Volume | 68 |
| Issue | 2 |
| Pages | 149-155 |
| Publication date | 1985-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330680202 |
| PMID | 2998196 |
| OpenAlex | W2165290518 |
| Language | EN |
| Citations received | 61 |
| References cited | 26 |
Southwestern American Indian (Amerindian) mitochondrial DNAs (mtDNAs) were analyzed with restriction endonucleases and found to contain Asian restriction fragment length polymorphisms (RFLPs) but at frequencies very different from those found in Asia. One rare Asian HincII RFLP was found in 40% of the Amerindians. Several mtDNAs were discovered which have not yet been observed on other continents and different tribes were found to have distinctive mtDNAs. Since the mtDNA is inherited exclusively through the maternal lineage, these results suggest that Amerindian tribes were founded by small numbers of female lineages and that new mutations have been fixed in these lineages since their separation from Asia
Biology · Evolutionary biology · Founder effect · Gene · Genotype · Haplotype · Mitochondrial DNA · Forensic and Genetic Research · Genetics · Metabolism and Genetic Disorders · RNA and protein synthesis mechanisms
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| Unique citing works | 61 |
|---|---|
| Citations per year | 1,52 |
| Citation span | 1986 - 2021 (36) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 54 |