Altitude, language, and class I HLA allele frequencies in Papua New Guinea
Bibliographic Data
| ID | 8312352 |
|---|---|
| Authors | Tom Smith (0000-0001-5084-8729, Papua New Guinea Institute of Medical Research, corresponding author), Kuldeep Bhatia (Papua New Guinea Institute of Medical Research), Madhuri Prasad (Papua New Guinea Institute of Medical Research), George Koki (Papua New Guinea Institute of Medical Research), Michael P Alpers (Papua New Guinea Institute of Medical Research), Michael Alpers |
| Year | 1994 |
| Volume | 95 |
| Issue | 2 |
| Pages | 155-168 |
| Publication date | 1994-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330950204 |
| PMID | 7802093 |
| OpenAlex | W1986113642 |
| Language | EN |
| Citations received | 4 |
| References cited | 26 |
Class I HLA gene frequencies show considerable variation over short geographical distances in Papua New Guinea. Hypotheses to account for this invoke natural selection, population structure, the pattern of population movement, or past demographic changes. To determine the role of the various factors in shaping this distribution, we have studied correlations between HLA‐based genetic distances, geographical distances, altitude, and linguistic differences in Papua New Guinea. Linguistic differences at the family or stock level within the Trans‐New Guinea Phylum generally correspond to genetic differences. However, on the basis of their HLA gene frequencies, speakers of Austronesian (AN) languages do not form a distinct group of populations. Linguistic variation and spatial autocorrelation do not fully account for the altitudinal cline differences noted in gene frequencies, particularly at the HLA‐A locus. We propose that the distribution of HLA gene frequencies in Papua New Guinea is partially under the control of selection operating differentially along the altitude gradient. © 1994 Wiley‐Liss, Inc
Allele · Allele frequency · Altitude (triangle) · Biology · Cline (biology) · Ethnology · Evolutionary biology · Gene · Geography · Human leukocyte antigen · Locus (genetics) · Natural selection · New guinea · Population · Sociology · Chemokine receptors and signaling · Demography · Genetics · History · interferon and immune responses · Mathematics · T-cell and B-cell Immunology
Some distance properties of latent root and vector methods used in multivariate analysis
Genetic Distance between Populations
Multiple Regression and Correlation Extensions of the Mantel Test of Matrix Correspondence
Partial correlation of distance matrices in studies of population structure
Comparison of distance matrices in studies of population structure and genetic microdifferentiation
Antigen and haplotype frequencies at three human leucocyte antigen loci (HLA‐A, ‐B, ‐C) in the Pawaia of Papua New Guinea
Genetic changes across language boundaries in Europe
Matrix correlation analysis in anthropology and genetics
Melanesian gene frequencies
Linguistic prehistory in the New Guinea area
Population change and distribution in Papua New Guinea
Linguistic and genetic differentiation in New Guinea
Human geography of Papua New Guinea
| Unique citing works | 4 |
|---|---|
| Citations per year | 0,13 |
| Citation span | 1995 - 2001 (7) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |