Schistosomiasis and hydration status
Schistosoma haematobium , but not Schistosoma mansoni increases urine specific gravity among rural Tanzanian women
Bibliographic Data
Objectives Schistosome infections can damage organs important for water homeostasis, especially the kidneys. Urogenital schistosomiasis (caused by Schistosoma haematobium) increases protein and blood in urine and intestinal schistosomiasis (caused by S. mansoni) affects total body water. However, no data exist on how different schistosome species affect urine specific gravity (USG), a hydration biomarker. Therefore, we assessed the relationship between S. haematobium ‐ and S. mansoni‐ infected and uninfected women and USG in rural Tanzania. Materials and methods Surveys were conducted and stool and urine samples were collected among 211 nonpregnant women aged 18–50. S. haematobium eggs were detected using the urine filtration method. S. mansoni eggs were detected using the Kato Katz method. USG was measured using a refractometer and analyzed as both a continuous and dichotomous variable. Regression (linear/logistic) models were estimated to test the relationship between infection and hydration status. Results The prevalence of S. haematobium was 5.9% and S. mansoni was 5.4% with no coinfections. In regression models, S. haematobium ‐infected women had significantly higher USG (Beta = 0.007 g mL −1 ; standard error = 0.002; p = 0.001) and odds (Odds ratio: 7.76, 95% CI: 1.21‐49.5) of elevated USG (>1.020 g mL −1 ) than uninfected women, whereas S. mansoni ‐infected women did not. Discussion Schistosoma haematobium , but not S. mansoni , infection is associated with higher USG and risk of inadequate hydration. Future work should determine whether findings are attributable to parasite‐induced debris in urine or urinary tract pathologies and signs of renal damage. Human and non‐human primate studies using USG in schistosome‐endemic areas should account for schistosomiasis
Biology · Helminthiasis · Helminths · Schistosoma haematobium · Schistosoma mansoni · Schistosomiasis · Urine · Urine specific gravity · Immunology · Internal Medicine · Medicine · Paleopathology and ancient diseases · Parasite Biology and Host Interactions · Parasites and Host Interactions · Physiology
A solution to the problem of separation in logistic regression
Estimating predicted probabilities from logistic regression
Water, hydration, and health
Prevalence,awareness and factors associated with hypertension in North West Tanzania
Dehydration among lactating mothers in the A mazon
Specific gravity as an alternative to creatinine for estimating urine concentration in captive and wild chimpanzee ( Pan troglodytes ) Samples
The Anthropology of Infectious Disease
Assessment of body hydration in subjects with schistosomiasis
Irrigation and infection
An evolutionary framework for assessing illness and injury in nonhuman primates
Heat and hydration status
Tropical environments, human activities, and the transmission of infectious diseases
Dancing skeletons-life and death in West Africa
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,29 |
| Citation span | 2019 - 2020 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |