The Bacon Chow study
Genetic analysis of physical growth in assessment of energy–protein malnutrition
Bibliographic Data
| ID | 8313850 |
|---|---|
| Authors | William H Mueller (The University of Texas Health Science Center at Houston), Ernesto Pollitt (The University of Texas Health Science Center at Houston) |
| Year | 1983 |
| Volume | 62 |
| Issue | 1 |
| Pages | 11-17 |
| Publication date | 1983-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330620104 |
| PMID | 6414308 |
| OpenAlex | W2087343605 |
| Language | EN |
| Citations received | 3 |
| References cited | 16 |
Estimates of the prevalence of energy–protein malnutrition almost universally employ physical growth measurements. In this study we focus on this disease and the role of body size of relatives as mediators of responses in individuals to one type of nutrition intervention: supplementation of pregnant and lactating women. In this study, initiated by Dr. Bacon Chow and others in 1967, during gestation of a first infant a mother was untreated, while during the lactation of the first infant and the gestation and lactation of a second infant she was treated with either a calorie supplement or a placebo. Supplement–placebo group differences were sought in sibling and mother–child correlations in growth from birth to 30 months, in order to assess the role of heredity as a mediator of supplement effects. There were 108 pairs of siblings whose mothers had received a high‐calorie–high‐protein supplement as described above and 105 pairs of siblings whose mothers had received a placebo. Among the latter, sibling correlations for most measurements are statistically significant at birth, and of the same magnitude seen in previous studies (∼0.5), while among supplemented siblings, birth correlations are unusually low and often insignificant. The sibling correlations in Rohrer's index (wt/L 3 ) differed the most between groups (p both supplement groups mother–second child correlations for body weight were higher than mother–first child correlations, suggesting the occurrence of secular changes in the environment unconnected with the treatment. The results suggest that: (1) genetic analysis of components of anthropometric variation may be a more sensitive method than the more conventional comparison of group means in detecting supplement effects; and (2) infant relative weight (Rohrer index), particularly the addition of subcutaneous fat, may be more affected by maternal supplementation than growth in weight or length alone
Biology · Birth order · Calorie · Developmental psychology · Environmental health · Gestation · Heredity · Lactation · Malnutrition · Placebo · Population · Pregnancy · Sibling · Child Nutrition and Feeding Issues · Child Nutrition and Water Access · Demography · Endocrinology · Genetics · Internal Medicine · Medicine · Obesity, Physical Activity, Diet · Psychology · Pediatrics
Sibling correlations for growth status in schoolchildren from a rural community in Oaxaca, Mexico
Familial similarity in body size in an isolated Zapotec-speaking community in the valley of Oaxaca, southern Mexico
Genetic and environmental effects on growth of children from a subsistence agricultural community in Southern Mexico
Sibling correlations in growth and adult morphology in a rural Colombian population
Genetic and environmental determinants of growth of school-aged children in a rural Colombian population
The relationship between children's and parents' heights in the age-range 0 – 6 years
Human physical growth and maturation. Methodologies and factors
Socioeconomic Life in Rural Taiwan
| Citations per year | 0.07 |
|---|---|
| Citation span | 1986 - 2005 (20) |
| Highly cited | No |