Admixed ancestry and stratification of Quebec regional populations

Bibliographic Data

ID8314010
AuthorsClaude Bherer (0000-0002-2744-7246, Université du Québec à Chicoutimi), Damian Labuda (0000-0002-2199-1996, Centre Hospitalier Universitaire Sainte-Justine), Marie‐Hélène Roy‐Gagnon (0000-0001-8747-0846, Centre Hospitalier Universitaire Sainte-Justine), Louis Houde (Université du Québec à Chicoutimi), Marc Tremblay, Marc Adélard Tremblay (Université du Québec à Chicoutimi), Hélène Vézina (0000-0002-3002-309X, Université du Québec à Chicoutimi, corresponding author)
Year2011
Volume144
Issue3
Pages432-441
Publication date2011-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.21424
PMID21302269
OpenAlexW1970359971
LanguageEN
Citations received6
References cited29

Population stratification results from unequal, nonrandom genetic contribution of ancestors and should be reflected in the underlying genealogies. In Quebec, the distribution of Mendelian diseases points to local founder effects suggesting stratification of the contemporary French Canadian gene pool. Here we characterize the population structure through the analysis of the genetic contribution of 7,798 immigrant founders identified in the genealogies of 2,221 subjects partitioned in eight regions. In all but one region, about 90% of gene pools were contributed by early French founders. In the eastern region where this contribution was 76%, we observed higher contributions of Acadians, British and American Loyalists. To detect population stratification from genealogical data, we propose an approach based on principal component analysis (PCA) of immigrant founders' genetic contributions. This analysis was compared with a multidimensional scaling of pairwise kinship coefficients. Both methods showed evidence of a distinct identity of the northeastern and eastern regions and stratification of the regional populations correlated with geographical location along the St‐Lawrence River. In addition, we observed a West‐East decreasing gradient of diversity. Analysis of PC‐correlated founders illustrates the differential impact of early versus latter founders consistent with specific regional genetic patterns. These results highlight the importance of considering the geographic origin of samples in the design of genetic epidemiology studies conducted in Quebec. Moreover, our results demonstrate that the study of deep ascending genealogies can accurately reveal population structure. Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc

Biology · Economic geography · Evolutionary biology · Gene · Genealogy · Genetic epidemiology · Geography · Immigration · Kinship · Population · Population stratification · Sociology · Stratification (seeds) · Anthropology · Demography · Forensic and Genetic Research · Genetic Associations and Epidemiology · Genetics · History · Race, Genetics, and Society

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