Predictors of delayed‐type hypersensitivity to Candida albicans and anti‐epstein‐barr virus antibody among children in Kilimanjaro, Tanzania

Bibliographic Data

ID8315535
AuthorsK Wander (0000-0002-4913-5075, University of Washington, corresponding author), Bettina Shell‐duncan (0000-0001-5020-5029, Department of Anthropology University of Washington Seattle WA 98195), Eleanor Brindle (0000-0002-4272-0909, Center for Studies in Demography and Ecology University of Washington Seattle WA 98195), Kathleen O’connor (0000-0003-2948-8911, University of Washington), Kathleen O'Connor (0000-0002-5910-140X, Department of Anthropology University of Washington Seattle WA 98195)
Year2013
Volume151
Issue2
Pages183-190
Publication date2013-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.22250
PMID23460387
PMCIDPMC4005610
OpenAlexW1532962415
LanguageEN
Citations received4
References cited32

We evaluated sex, age, nutritional status, and infectious disease (ID) as predictors of two biomarkers of cell‐mediated immunity (CMI), delayed‐type hypersensitivity to Candida albicans (DTH‐ Candida ), and anti‐Epstein‐Barr virus antibody (EBV Ab), among 200 children in Kilimanjaro, Tanzania. DTH‐ Candida, which decreases with compromised CMI, was positively associated with age (OR: 1.27; 95% CI: 1.02, 1.57) and triceps skinfold (TSF; OR: 1.16; 95% CI: 1.02, 1.26), and inversely associated with height‐for‐age Z score (HAZ; OR: 0.86; 95% CI: 0.68, 1.08) and diagnosed ID (OR: 0.48; 95% CI: 0.22, 1.08). There was significant interaction between TSF and ID: DTH‐ Candida exhibited a strong inverse association with ID among children with low TSF (OR: 0.16; 95% CI: 0.05, 0.50) and a strong positive association with TSF among children with ID (OR: 2.64; 95% CI: 1.29, 5.42). EBV Ab, which increases with compromised CMI, was inversely associated with male sex (β: −0.47; 95% CI: −0.70, −0.24) and TSF (β: −0.04; 95% CI: −0.08, 0.00), and positively associated with HAZ (β: 0.06; 95% CI: −0.03, 0.15). Among males, EBV Ab was positively associated with anemia. Among normal HAZ children, EBV Ab was inversely associated with TSF. There was no association between DTH ‐Candida and EBV Ab. While DTH‐ Candida provides a direct measure of CMI, our results suggest that interpretation of EBV‐Ab among Kilimanjaro children was complicated by its indirect relationship with CMI. Among our sample, CMI increased with age and adequate nutrition and was compromised during acute ID. The suggestive CMI‐compromising effect of increasing height‐for‐age may bear further exploration. Am J Phys Anthropol 151:183–190, 2013. © 2013 Wiley Periodicals, Inc

Antibody · Biology · Candida albicans · Immune system · Immunity · Asthma and respiratory diseases · Drug-Induced Adverse Reactions · Immunodeficiency and Autoimmune Disorders · Immunology · Internal Medicine · Medicine · Microbiology

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