Genetic studies in the Markham Valley, northeastern Papua New Guinea

Gamma globulin (Gm and Inv), group specific component (Gc) and ceruloplasmin (Cp) typing

Bibliographic Data

ID8315591
AuthorsM S Schanfield (University of Michigan), Eugene Giles (University of Illinois Urbana-Champaign), H Gershowitz (University of Michigan)
Year1975
Volume42
Issue1
Pages1-7
Publication date1975-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330420102
PMID46722
OpenAlexW2006625426
LanguageEN
Citations received13
References cited9

Genetic studies in the Markham Valley, northeastern Papua New Guinea: Gamma globulin (Gm and Inv), group specific component (Gc) and ceruloplasmin (Cp) typing. M. S. Schanfield, Eugene Giles and H. Gershowitz, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48104. Immunoglobulin allotyping was carried out on 680 serum samples from inhabitants of the Markham Valley, Papua New Guinea (seven villages speaking the same Melanesian [MN] language and a single Papuan [PAP] speaking village). Family and population data verified the presence of Gm ag , and Gm afb among the MN speakers and Gm ag , Gm axg , Gm ab and Gm afb among the PAP speakers. The frequency of Gm ag was between 0.048 and 0.235, while the frequency of Gm ab was between 0.427 and 0.627 and the frequency of Gm afb ranged between 0.261 and 0.424 among the seven MN villages; the single PAP village had frequencies of 0.568, 0.160, 0.213 and 0.059 for Gm ag , Gm axg , Gm ab and Gm afb respectively. The frequency of Inv 1 ranged between 0.034 and 0.095 in the MN villages and 0.014 in the PAP village. The rare occurrence of Gm(x) without Gm(g) could be studied in three families. In an MN family the presence of Gm(x) without Gm(g) was explained by the presence of a Gm axfb haplotype, while in two PAP families the presence of Gm(x) without Gm(g) was explained by the abnormally weak expression of Gm(g) in a Gm axg haplotype. A total of 654 sera were typed for Gc, with the seven MN villages ranging between 0.350 and 0.650 for Gc 1 , 0.312 and 0.575 for Gc 2 and between 0.017 and 0.112 for Gc Ab ; the single PAP village had a value of 0.627 for Gc 1 , 0.165 for Gc 2 and 0.208 for Gc Ab . A total of 693 sera were tested for ceruloplasmin type. All showed the common Cp(b) phenotype

Allele frequency · Biology · Ceruloplasmin · Gene · Genotype · Globulin · Haplotype · Population · Sociology · Typing · Veterinary medicine · Biochemistry · Demography · Forensic and Genetic Research · Genetics · Immunology · Medicine

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