Kin‐structured migration and the rate of advance of an advantageous gene

Datos Bibliográficos

ID8318804
AutoresAlan G Fix (University of California, Riverside, autor de correspondencia)
Año1981
Volumen55
Número4
Páginas433-442
Fecha de publicación1981-08-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0002-9483 • E-ISSN: 1096-8644
EditorialWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330550404
OpenAlexW1971066515
IdiomaEN
Citas recibidas6
Referencias citadas18

Hemoglobin E, an allele generally considered to confer malarial resistance in heterozygotes, is found in high frequencies across a wide area of Southeast Asia. Apparently it originated as a single‐point mutation which was spread by gene flow. The rate of diffusion of this adaptive allele is studied using four computer simulation models. It is shown that in small populations deterministic equations for gene flow may overestimate rates of diffusion. Other aspects of population structure, however, such as kin‐structuring of migrant groups, increase the rate of advance. Finally, population growth coupled with the spread of the allele leads to much more rapid diffusion. These results suggest that population structure can be an important factor affecting the diffusion of advantageous genes

Allele · Biology · Diffusion · Evolutionary biology · Gene · Gene flow · Genetic variation · Physics · Population · Sociology · Thermodynamics · Animal Behavior and Reproduction · Demography · Evolution and Genetic Dynamics · Genetics · Mathematical and Theoretical Epidemiology and Ecology Models