The effects of single gene substitution on the mammalian melanocyte system—a qualitative and quantitative histological study in the C57BL and DBL mice
Bibliographic Data
| ID | 8318874 |
|---|---|
| Authors | Donald E Gerson (Harvard University), George Szabo (0000-0002-8553-1227, Harvard University, corresponding author) |
| Year | 1969 |
| Volume | 31 |
| Issue | 3 |
| Pages | 363-381 |
| Publication date | 1969-11-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330310312 |
| OpenAlex | W2023367628 |
| Language | EN |
| Citations received | 2 |
| References cited | 14 |
About 160 skin samples from the tail, sole, palm, ear and scrotum of DBL and C57BL/St mice were “split” with NaBr and treated with DOPA. A quantitative and qualitative microscopic analysis showed that: (a) the two strains did not differ consistently in the frequency of epidermal or dermal melanocytes; nor did the sexes differ from each other in this respect; (b) the melanocytes of the two strains differed morphologically. The DBL melanocytes were generally larger, with melanin‐congested perikarya. They had fewer dendrites than the C57BL melanocytes and their dendrites were shorter; and (c) the melanocytes of the DBL and C57BL strains differed in activity, the DBL melanocytes donating less melanin to Malpighian cells than did the C57BL melanocytes. It was concluded that the morphology of DBL and C57BL melanocytes is largely autonomously determined, although regional differences in melanocyte morphology suggest that the cellular environment also plays some part in influencing melanoblast differentiation
Biology · C57BL/6 · Gene · Melanin · Melanocyte · Melanoma · Melanosome · Phenotype · Cell Biology · Endocrinology · Genetics · melanin and skin pigmentation
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,04 |
| Citation span | 1975 - 1977 (3) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |