Menopause effect on blood Fe and Cu isotope compositions
Bibliographic Data
| ID | 8319214 |
|---|---|
| Authors | K Jaouen (0000-0003-2820-5035, Department of Human Evolution Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany, corresponding author), Vincent Balter (0000-0002-9236-4834, Laboratoire de Géologie de Lyon UMR 5276 CNRS ENS Lyon Université Lyon 1 47 allée d'Italie 69007 Lyon France) |
| Year | 2014 |
| Volume | 153 |
| Issue | 2 |
| Pages | 280-285 |
| Publication date | 2014-02-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.22430 |
| PMID | 24263674 |
| OpenAlex | W1591136305 |
| Language | EN |
| Citations received | 4 |
| References cited | 29 |
Iron (δ 56 Fe) and copper (δ 65 Cu) stable isotope compositions in blood of adult human include a sex effect, which still awaits a biological explanation. Here, we investigate the effect of menopause by measuring blood δ 56 Fe and δ 65 Cu values of aging men and women. The results show that, while the Fe and Cu isotope compositions of blood of men are steady throughout their lifetime, postmenopausal women exhibit blood δ 65 Cu values similar to men, and δ 56 Fe values intermediate between men and premenopausal women. The residence time of Cu and Fe in the body likely explains why the blood δ 65 Cu values, but not the δ 56 Fe values, of postmenopausal women resemble that of men. We suggest that the Cu and Fe isotopic fractionation between blood and liver resides in the redox reaction occurring during hepatic solicitation of Fe stores. This reaction affects the Cu speciation, which explains why blood Cu isotope composition is impacted by the cessation of menstruations. Considering that Fe and Cu sex differences are recorded in bones, we believe this work has important implications for their use as a proxy of sex or age at menopause in past populations. Am J Phys Anthropol 153:280–285, 2014. © 2013 Wiley Periodicals, Inc
Biology · Chromatography · Copper · Fractionation · Human blood · Isotope · Isotope fractionation · Menopause · Metallurgy · Chemistry · Endocrinology · Heavy Metal Exposure and Toxicity · Iron Metabolism and Disorders · Materials Science · Physiology · Trace Elements in Health
Historical overview and new directions in bioarchaeological trace element analysis
Stable isotope evidence (Fe, Cu) suggests that sex, but not aging is recorded in rhesus macaque ( Macaca mulatta ) bone
Copper and zinc isotope ratios in human bone and enamel
Potential of non-traditional isotope studies for bioarchaeology
| Citations per year | 0.44 |
|---|---|
| Citation span | 2017 - 2021 (5) |
| Highly cited | No |