The effect of sample attrition on the frequency distribution of blood pressure and genetic marker phenotypes representing a natural unselected community

Tecumseh, Michigan

Bibliographic Data

ID8320355
AuthorsDavid Glenn Smith (0000-0001-7858-3785, University of Michigan, corresponding author), Charles F Sing (0000-0001-5872-7956, University of Michigan, corresponding author)
Year1976
Volume44
Issue1
Pages139-149
Publication date1976-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330440120
PMID1247109
OpenAlexW2067955157
LanguageEN
References cited11

Highly significant differences in mean age, blood pressure and phenotype frequency distributions between the non‐migrants and “emigrants” of a total unselected community sample were discovered. Use of the mean of BP scores collected from epidemiologic surveys over a period of time as an individual score allows sample attrition to produce both a genetically and demographically biased sample of a population intended to represent an unselected community of people. Multiple regression analyses estimated the contribution of an individual's age, genotype and mobility out of the sample to predicting blood pressure variation. Variation in blood pressure means among certain marker phenotype classes was greater in those who leave than in those who stay, but only the upper portion of the pressure distribution contributed to this relationship. A genetic‐environment interaction is suggested

Attrition · Biology · Blood pressure · Gene · Phenotype · Population · Sample (material) · Birth, Development, and Health · Chemistry · Demography · Genetic Associations and Epidemiology · Genetics · Health, Environment, Cognitive Aging · Internal Medicine · Medicine

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