Hypothesis
A selective advantage for cystic fibrosis heterozygotes
Bibliographic Data
| ID | 8320640 |
|---|---|
| Authors | Richard S Meindl (Kent State University, corresponding author) |
| Year | 1987 |
| Volume | 74 |
| Issue | 1 |
| Pages | 39-45 |
| Publication date | 1987-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330740104 |
| PMID | 3318490 |
| OpenAlex | W2053385942 |
| Language | EN |
| Citations received | 4 |
| References cited | 14 |
European populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (CF). While carriers of the recessive gene are asymptomatic for CF disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be especially adaptive in host resistance to the human strain of Mycobacterium tuberculosis. CF heterozygosity may have been an adaptation to a disease environment once dominated by this infection
Allele · Asymptomatic · Biology · Compound heterozygosity · Cystic fibrosis · Disease · Gene · Heterozygote advantage · Loss of heterozygosity · Mycobacterium tuberculosis · Pathology · Phenotype · Tuberculosis · Virulence · Cystic Fibrosis Research Advances · Genetics · Immunology · Medicine · Microbiology · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology
The Cystic Fibrosis Heterozygote Advantage
A General Model of the Relationship between the Apportionment of Human Genetic Diversity and the Apportionment of Human Phenotypic Diversity
The Anthropology of Infectious Disease
The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis
| Unique citing works | 4 |
|---|---|
| Citations per year | 0,11 |
| Citation span | 1990 - 2015 (26) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |