Cytogenetic and fertility studies of a rheboon, rhesus macaque (Macaca mulatta) baboon (Papio hamadryas) cross

Further support for a single karyotype nomenclature

Bibliographic Data

ID8320718
AuthorsCharleen M Moore (The University of Texas at San Antonio Health Science Center, corresponding author), Cathy Janish, Carlton A Eddy (The University of Texas at San Antonio Health Science Center), Gene B Hubbard (Texas Biomedical Research Institute), M Michelle Leland (Texas Biomedical Research Institute), Jeffrey Rogers (0000-0002-7374-6490, Texas Biomedical Research Institute)
Year1999
Volume110
Issue2
Pages119-127
Publication date1999-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/(sici)1096-8644(199910)110:2<119::aid-ajpa1>3.0.co;2-s
PMID10502238
OpenAlexW1964629882
LanguageEN
Citations received5
References cited20

Historically, two different numbering systems have been used to describe the baboon and macaque karyotypes. However, G-banding studies and, more recently, fluorescence in situ hybridization results have shown that the two karyotypes are virtually identical. To confirm this hypothesis, cytogenetic analysis of an unusual animal, a rheboon, was undertaken. The rheboon reported here, an 18-year-old male, is the only long-term survivor of 26 pregnancies resulting from matings between female baboons (Papio hamadryas) and male rhesus macaques (Macaca mulatta). A G-banded karyotype was prepared from the rheboon and compared with the karyotypes of the two parental species. Spectral karyotyping (SKY) was carried out on the rheboon chromosomes, and the results were compared with SKY studies reported for the baboon and with CISS (chromosome in situ suppression) studies in the rhesus macaque. No differences were detected in any of the rheboon's pairs of autosomes, reinforcing the apparent identity of the two parental karyotypes. Based on these results, we argue that a single karyotyping system should be adopted for the two species. Fertility studies were initiated to determine if the rheboon is sterile, as are most hybrid animals. Two semen ejaculates were devoid of sperm. A testicular biopsy revealed hypoplasia of the seminiferous tubules with few Leydig cells and large lumena. Meiotic arrest occurred during meiosis I, resulting in absence of mature spermatozoa. Thus, the testicular and meiotic findings in the rheboon were similar to those observed in other hybrids, even though the parental karyotypes appear identical.

Andrology · Autosome · Baboon · Biology · Chromosome · Karyotype · Macaque · Meiosis · Rhesus macaque · Endocrinology · Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities · Genetics · Primate Behavior and Ecology · Sperm and Testicular Function

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