Effect of coca‐leaf chewing on salivary progesterone assays
Bibliographic Data
| ID | 8320784 |
|---|---|
| Authors | J Vitzthum (0000-0002-6765-4557, University of California, Riverside, corresponding author), Virginia J Vitzthum, Miranda Von Dornum (Harvard University), Peter M Elias (0000-0002-0069-9064, Harvard University), Peter T Ellison |
| Year | 1993 |
| Volume | 92 |
| Issue | 4 |
| Pages | 539-544 |
| Publication date | 1993-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330920410 |
| PMID | 8296880 |
| OpenAlex | W1978645516 |
| Language | EN |
| Citations received | 12 |
| References cited | 19 |
Although there is evidence for reduced fertility in Andean and Himalayan populations at higher altitudes, factors other than hypoxia may be primarily responsible. A valuable approach in the investigation of these fertility determinants is the use of salivary steroid assays. However, coca‐leaf chewing—a ubiquitous practice among high altitude Andean populations—has negative consequences for the accurate measurement of ovarian steroids. This report evaluates the effects of coca‐leaf chewing on assays of salivary progesterone. Study participants include naive and habitual users of coca leaf from La Paz and El Alto, Bolivia. Approximately 300 saliva samples were collected immediately before, during, and after coca‐leaf chewing. The series includes samples with and without the alkaloid enhancer typically used by coca‐leaf chewers. Coca chewing produces false salivary progesterone values that mimic luteal phase values. On the basis of this study, an appropriate protocol is developed for the collection of salivary samples in coca‐leaf chewing populations. These results verify the feasibility of salivary assays, even for very difficult field conditions, and highlight the necessity of establishing suitable collection procedures before full field implementation of saliva sampling. © 1993 Wiley‐Liss, Inc
Coca · Saliva · Salivary Proteins · Traditional medicine · Adrenal Hormones and Disorders · Biochemistry · Chemistry · High Altitude and Hypoxia · Medicine · Stress Responses and Cortisol
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| Unique citing works | 12 |
|---|---|
| Citations per year | 0,63 |
| Citation span | 2007 - 2026 (20) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 12 |