Genetic Determination of Head-Size-Related Anthropometric Traits in an Ethnically Homogeneous Sample of 373 Indian Pedigrees of West Bengal

Bibliographic Data

ID8960573
AuthorsBibha Karmakar (Indian Statistical Institute, corresponding author), Sergey Ermakov (0000-0002-5679-1775, Indian Statistical Institute, corresponding author), K Yakovenko (Indian Statistical Institute, corresponding author), E Kobyliansky (0000-0001-9691-3813, Indian Statistical Institute, corresponding author)
Year2007
Volume79
Issue5
Pages501-514
Publication date2007-10-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueHuman Biology (JOURNAL)
Journal identifiersISSN: 0018-7143 • E-ISSN: 1534-6617
PublisherHuman Biology (The International Journal of Population Biology and Genetics) (PUBLISHER)
DOI10.1353/hub.2008.0007
PMID18478966
OpenAlexW1608347152
LanguageEN
Citations received4
References cited3

The substantial involvement of genetic factors in the determination of head-size and head-shape traits has been firmly established. However, there has been a lack of agreement on a number of specific issues concerning the pattern of inheritance of craniofacial features. In this study we examined some of these issues in a large, ethnically homogeneous sample of Indian pedigrees. The data included 1,263 individuals belonging to 373 nuclear families. Eleven raw head-size traits and two synthetic phenotypes, interpreted as horizontal and vertical head-size components (HOC and VEC, respectively), were used in the analysis. To establish the pattern of inheritance of head traits, we carried out univariate and bivariate analyses. Maximum heritability estimates ranged from 0.41 to 0.83 for the studied head-size phenotypes. The portion of the total residual variance attributable to putative additive genetic factors was 68.3% and 70.3% for HOC and VEC, respectively, and common familial factor effects were found to be nonsignificant. The extent of genetic influences did not differ significantly with respect to sex or between HOC and VEC. The results of bivariate variance decomposition analysis strongly suggest the existence of common genetic factors simultaneously affecting HOC and VEC; 41.8% of the two traits' total residual variance was attributable to the effect of these common genetic factors

Biology · Bivariate analysis · Heritability · Multivariate statistics · Pedigree chart · Sample size determination · Statistics · Univariate · Craniofacial Disorders and Treatments · Demography · Forensic Anthropology and Bioarchaeology Studies · Genetics · Mathematics · Orthodontics and Dentofacial Orthopedics

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