Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study

Our study suggests that meat intake may activate TLRs at the epithelial surface, leading to CRC via inflammation by nuclear transcription factor-κB-initiated transcription of inflammatory genes, whereas intake of fiber may protect against CRC via TLR4-mediated secretion of interleukin-10 and cyclooxygenase-2. Our results should be replicated in other prospective cohorts with well-characterized participants. The trial was registered at www.clinicaltrials.gov as NCT03250637.

Business · Business administration · Political science · Regional Development and Policy

• Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD)

  Open Access•Nathalie Fogh Rasmussen, Bodil Hammer Bech et al.•BMC Public Health•2021

  Añadir item

• What's wrong with Bonferroni adjustments

  Open Access•Thomas V Perneger, Thomas Perneger•BMJ•1998

  Añadir item

• The International HapMap Project

  Open Access•Richard A Gibbs, John W Belmont et al.•Nature•2003

  Añadir item

• A simple salting out procedure for extracting DNA from human nucleated cells

  Open Access•S A Miller, Dale D Dykes et al.•Nucleic Acids Research•1988

  Añadir item