An interaction between perceived stress and 5HTTLPR genotype in the prediction of stable depressive symptomatology
Bibliographic Data
| ID | 9052359 |
|---|---|
| Authors | Kevin M Beaver (0000-0003-3042-3496, Florida State University), Michael G Vaughn (0009-0003-1189-8610, UCLouvain Saint-Louis Brussels), John Paul Wright, John Wright (0000-0001-9572-7293, University of Cincinnati), Matt Delisi (0000-0001-5964-5848, Iowa State University) |
| Year | 2012 |
| Volume | 82 |
| Issue | 2 |
| Pages | 260-266 |
| Publication date | 2012-04-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Orthopsychiatry (JOURNAL) |
| Journal identifiers | ISSN: 0002-9432 • E-ISSN: 1939-0025 |
| Publisher | American Psychological Association (APA) (PUBLISHER) |
| DOI | 10.1111/j.1939-0025.2012.01148.x |
| PMID | 22506528 |
| OpenAlex | W1977826758 |
| Language | EN |
| Citations received | 2 |
| References cited | 26 |
A significant amount of research has examined the interaction between a functional polymorphism in the serotonin transporter gene (5HTTLPR) and stressful life events in the prediction of depression and depressive symptomatology. The results of these studies have produced conflicting evidence, with some studies substantiating a significant interaction and others failing to detect a significant interaction. The purpose of the current study was to add to this line of research by testing for an interaction between 5HTTLPR and perceived stress in the prediction of stable depressive symptomatology. Analysis of data from the National Longitudinal Study of Adolescent Health (Add Health) indicates that the association between perceived stress and depression is moderated by 5HTTLPR genotype for females, but not for males. Specifically, females who were homozygous for the short allele were significantly more likely to report symptoms of depression in the face of perceived stress when compared to females who were homozygous or heterozygous for the long allele
Anxiety · Association (psychology) · Depression (economics) · Depressive symptoms · Gene · Genotype · Longitudinal study · Psychiatry · Serotonin transporter · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Early Childhood Education and Development · Genetics · Medicine · Psychology · Stress Responses and Cortisol
Genetic Sensitivity to the Environment
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Influence of Life Stress on Depression
The National Longitudinal Study of Adolescent Health (Add Health) Twin Data
Protecting Adolescents From Harm
Comparison of two modes of stress measurement
The CES-D Scale
Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men
On the relationship of hardiness to the Type A behavior pattern
Using the Correct Statistical Test for the Equality of Regression Coefficients
Genotype-environment interaction and sociology
A Global Measure of Perceived Stress
| Citations per year | 0.15 |
|---|---|
| Citation span | 2013 - 2023 (11) |
| Highly cited | No |