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Comparative Effectiveness Research Methods

Symposium Overview and Summary

Bibliographic Data

ID9099477
AuthorsKathleen N Lohr (0000-0002-3825-0713, RTI International, corresponding author)
Year2010
Volume48
Issue6
PagesS3-S6
Publication date2010-06-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/mlr.0b013e3181e10434
PMID20473188
OpenAlexW1971236349
LanguageEN
Citations received1
References cited24

BACKGROUND: The Agency for Healthcare Research and Quality, in expanding its efforts to advance methods for comparative effectiveness research (CER), convened a second invitational symposium in June 2009 through its Developing Evidence to Inform Decisions About Effectiveness (DEcIDE) network. A distinguished Planning Committee set the agenda, reviewed more than 70 abstracts, and invited almost 30 speakers; the program emphasized issues of clinical heterogeneity and longitudinal outcomes, including patient-reported measures. RESULTS: Conference papers covered a varied set of points about 3 major areas of CER: study design and data collection issues; statistical and analytic techniques; and applications to policy and clinical decision-making. Both primary data collection and analyses of databases (including electronic health records and distributed networks) are crucial for the CER agenda. Methods advances enable investigators to pay greater attention to important population subgroups, including persons of low literacy, non-English speaking patients, or the frail elderly. Both established and newer statistical techniques--eg, propensity scoring and various types of modeling, including Bayesian approaches--offer analysts improved ways to address issues such as confounding and measurement bias. Finally, some articles provided guidance for and examples of extending CER into newer realms, such as evaluations of medical devices or surgical procedures, and providing better information for decision-makers, clinicians, and patients

Agency (philosophy) · Comparative effectiveness research · Data collection · Data science · Health care · Health literacy · Health services research · Literacy · Management science · Medical education · MEDLINE · Patient-centered outcomes · Political science · Population · Research design · Set (abstract data type) · Chronic Disease Management Strategies · Computer Science · Engineering · Health Policy Implementation Science · Health Systems, Economic Evaluations, Quality of Life · Medicine · Nursing · Psychology

  • Reducing Bias in the Assessment of Treatment Effectiveness

    Yong-Fang Kuo, James E Montie et al.•Medical Care•2012

  • Who Can Respond to Treatment

    Sherrie H Kaplan, John Billimek et al.•Medical Care•2010

  • A Framework for Evidence Evaluation and Methodological Issues in Implantable Device Studies

    Art Sedrakyan, Danica Marinac-Dabic et al.•Medical Care•2010

  • Practice Based Evidence

    Susan D Horn, Julie Gassaway•Medical Care•2010

  • Evaluating Health Outcomes in the Presence of Competing Risks

    Ravi Varadhan, Carlos O Weiss et al.•Medical Care•2010

  • Validation of an Algorithm for Categorizing the Severity of Hospital Emergency Department Visits

    Dustin W Ballard, Mary Price et al.•Medical Care•2010

  • Comparative Effectiveness Research in DARTNet Primary Care Practices

    Anne M Libby, Wilson Pace et al.•Medical Care•2010

  • Rethinking Analytical Strategies for Surveillance of Medical Devices

    Sharon‐Lise T Normand, Sharon-Lise Normand et al.•Medical Care•2010

  • Assessing Medication Exposures and Outcomes in the Frail Elderly

    Stephen Crystal, Dorothy Gaboda et al.•Medical Care•2010

  • The Volume-Outcome Relationship in Nursing Home Care

    Yue Li, Xueya Cai et al.•Medical Care•2010

  • Confounding Control in Healthcare Database Research

    M Alan Brookhart, Til Stürmer et al.•Medical Care•2010

  • Electronic Patient-Reported Data Capture as a Foundation of Rapid Learning Cancer Care

    Amy P Abernethy, Asif Ahmad et al.•Medical Care•2010

  • Translating Comparative Effectiveness Into Practice

    Nilay D Shah, Rebecca J Mullan et al.•Medical Care•2010

  • Using Mechanistic Models to Simulate Comparative Effectiveness Trials of Therapy and to Estimate Long-term Outcomes in HIV Care

    Mark S Roberts, Kimberly A Nucifora et al.•Medical Care•2010

  • Cluster Randomized Trials in Comparative Effectiveness Research

    Richard Platt, Samuel U Takvorian et al.•Medical Care•2010

  • Literacy-Fair Measurement of Health-Related Quality of Life Will Facilitate Comparative Effectiveness Research in Spanish-Speaking Cancer Outpatients

    Elizabeth A Hahn, Hongyan Du et al.•Medical Care•2010

  • Distributed Health Data Networks

    Jeffrey S Brown, John H Holmes et al.•Medical Care•2010

  • Defining Comparative Effectiveness Research

    Harold C Sox•Medical Care•2010

  • An Integrated Evidence Rating to Frame Comparative Effectiveness Assessments for Decision Makers

    Daniel A Ollendorf, Steven D Pearson•Medical Care•2010

  • Bayesian Meta-Analyses for Comparative Effectiveness and Informing Coverage Decisions

    Scott M Berry, Scott Berry et al.•Medical Care•2010

  • Privacy-Maintaining Propensity Score-Based Pooling of Multiple Databases Applied to a Study of Biologics

    Jeremy A Rassen, Daniel H Solomon et al.•Medical Care•2010

  • Coordinating Cancer Care

    Steven J Katz, Sarah T Hawley et al.•Medical Care•2010

  • Mitigating Systematic Measurement Error in Comparative Effectiveness Research in Heterogeneous Populations

    A C Carle•Medical Care•2010

  • Comparative Effectiveness Research and Policy

    Judith A Turner, William Hollingworth et al.•Medical Care•2010

  • Prediction Modeling Using EHR Data

    Jionglin Wu, Jason Roy et al.•Medical Care•2010

Unique citing works1
Citations per year0,07
Citation span2012 - 2012 (1)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 1

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